General
Preferred name
PODOFILOX
Synonyms
(+)-Shikonin ()
Podophyllotoxin ()
PPT ()
Podofilox(+)-Shikonin ()
Condyline ()
Condylox ()
NSC-24818 ()
Warticon ()
Podophyllotoxin-d6 ()
P&D ID
PD000047
CAS
11016-28-7
518-28-5
Tags
available
probe
nuisance
drug
Approved by
FDA
First approval
1990
Drug indication
Antimitotic
Verruca vulgaris
External genital and perianal wart
Condyloma
Drug Status
approved
Max Phase
4.0
Probe info
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
35
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
119
Organisms
6
Compound Sets
32
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NIH Mechanistic Set
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
Probe Miner (suitable probes)
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
ReFrame library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
47
Properties
(calculated by RDKit )
Molecular Weight
414.13
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
2
cLogP
2.41
TPSA
92.68
Fraction CSP3
0.41
Chiral centers
4.0
Largest ring
6.0
QED
0.76
Structural alerts
1
Tubulin modulation
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Pathway
Cytoskeletal Signaling
DNA Damage/DNA Repair
Cell Cycle/DNA Damage
cytoskeleton
Target
Microtubule
Topo II
IGF1R, TOP2A, TUBA4A, TUBB
Tubulin inhibitor
Microtubule/Tubulin
Member status
member
MOA
microtubule inhibitor, tubulin polymerization inhibitor
Indication
genital warts
Cellular injury category
Cytoskeletal
Biosynthetic Origin
Other (Shikimate)
Therapeutic Indication
Genital Warts
Therapeutic Class
Antimicrobial
Source data
