General
Preferred name
AMOXAPINE
Synonyms
CL-67772 ()
CL 67772,Asendin ()
Amoxapina ()
CL 67772 ()
CL-67,772 ()
Asendis ()
Defanyl ()
NSC-759559 ()
Asendin ()
CL 67,772 ()
P&D ID
PD000076
CAS
14028-44-5
Tags
available
drug
Approved by
FDA
First approval
1980
Drug indication
Major depressive disorder
Antidepressant
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Amoxapine is a dibenzoxazepine-derivative tricyclic antidepressant. (GtoPdb)
DESCRIPTION Tricyclic antidepressant; inhibits neuronal uptake of norepinephrine (LOPAC library)
Cell lines
0
Organisms
4
Compound Sets
30
Axon Medchem Screening Library
1333
Cayman Chemical Bioactives
17347
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1113
ChEMBL Drugs
CHEMBL1113
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00543
DrugBank Approved Drugs
DB00543
DrugCentral
191
DrugCentral Approved Drugs
191
DrugMAP
DMKITQE
DrugMAP Approved Drugs
DMKITQE
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
201
Ki Database
AMOXAPINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1113
MedChem Express Bioactive Compound Library
HY-B0991
NCATS Inxight Approved Drugs
R63VQ857OT
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
amoxapine
TargetMol Bioactive Compound Library
T1568
The Spectrum Collection
ZINC Tool Compounds
ZINC000000000931
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
313.1
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
3.43
TPSA
36.86
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
7.0
QED
0.81
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Selectivity
Uptake
MOA
norepinephrine transporter inhibitor
GlyT inhibitor
5-HT2A Antagonists
5-HT Reuptake Inhibitors
Norepinephrine Reuptake Inhibitors
norepinephrine reputake inhibitor
Target
Dopamine Receptor
Serotonin Transporter
Norepinephrine transporter
GlyT1b
GlyT2a
ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, HRH1, HRH4, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR3A, HTR6, HTR7, SLC6A2, SLC6A3, SLC6A4
Tricyclic antidepressant
Bacterial
Amino acid transporter,GlyT
Pathway
Neuroscience
Anti-infection
Autophagy
Member status
member
Indication
depression
Therapeutic Class
Antidepressants
Source data