General
Preferred name
Kaempherol
Synonyms
KAEMPFEROL ()
Kempferol ()
Robigenin ()
Kaempferol (NSC 407289) ()
Kaempferol hydrate ()
Swartziol ()
Pelargidenolon ()
Rhamnolutein ()
Rhamnolutin ()
Trifolitin ()
Populnetin ()
P&D ID
PD000231
CAS
520-18-3
Tags
natural product
drug candidate
nuisance
available
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Kaempferol is a flavonol, a type of flavonoid, naturally occuring in a variety of plants. It has antibacterial activity against Gram-negative Helicobacter pylori and is reported to inhibit H. pylori HsrA (homeostatic stress regulator) . (GtoPdb)
DESCRIPTION Inhibits complex I of the mitochondrial electron transport chain (Tocris Bioactive Compound Library)
DESCRIPTION Mitochondrial Ca2+ uniporter (MCU) activator; proapoptotic (Tocriscreen Total)
Cell lines
11
Organisms
10
Compound Sets
17
AdooQ Bioactive Compound Library
A10495
Cayman Chemical Bioactives
11852
Concise Guide to Pharmacology 2021/22
11052
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB01852
DrugMAP
DMHEMUB
EU-OPENSCREEN Bioactive Compound Library
EOS100804
Guide to Pharmacology
11052
MedChem Express Bioactive Compound Library
HY-14590
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
Kaempferol
TargetMol Bioactive Compound Library
T2177
The Spectrum Collection
Tocris Bioactive Compound Library
3603
Tocriscreen Total
External IDs
42
Properties
(calculated by RDKit )
Molecular Weight
286.05
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
4
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
2.28
TPSA
111.13
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
3
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Nonspecific/NOS
Flavonoid
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
Anti-infection
Apoptosis
Autophagy
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Target
ER
AKR1B1, ALOX15B, ALOX5, AR, CYP1B1, GLO1, HSD17B1, UGT3A1
Endogenous Metabolite
Estrogen Receptor/ERR
HIV
Mitophagy
Parasite
Estrogen/progestogen Receptor,Fatty Acid Synthase
Primary Target
Apoptosis Inducers
MOA
bone resorption inhibitor, estrogen-related receptor inverse agonist
Source data