General
Preferred name
NIALAMIDE
Synonyms
Nialamid ()
Niamidal ()
N-benzyl-3-(2-isonicotinoylhydrazino)propanamide ()
Niamid ()
NSC-124514 ()
P&D ID
PD000240
CAS
51-12-7
Tags
natural product
drug
available
Drug Status
withdrawn
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Monoamine oxidase inhibitor
(LOPAC library)
DESCRIPTION
Nialamide is used as an antidepressant for it is a monoamine oxidase inhibitor (MAOI) of the hydrazine class. It might be efficient under the combination action with 5-hydroxytryptophan in antidepressant.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
21
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
JUMP-Target 1 Compound Set
LOPAC library
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
298.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
2
cLogP
1.02
TPSA
83.12
Fraction CSP3
0.19
Chiral centers
0.0
Largest ring
6.0
QED
0.53
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Selectivity
MAO
Pathway
Metabolism
Neuroscience
Neuronal Signaling
Target
AOA
AOB
COMT
COMT, MAOA, MAOB
Monoamine Oxidase
MOA
monoamine oxidase inhibitor
ATC
N06AF02
Toxicity type
hepatic
Solubility
10 mM in DMSO
Source data
