General
Preferred name
FLUMAZENIL
Synonyms
RO 15-1788 ()
Flumazenil (RO 15-1788) ()
[11C]flumazenil ()
RO-41-8157 ()
RO-151788 ()
RO 15-1788/000 ()
ANEXATE ()
LANEXAT ()
MAZICON ()
RO-1722 ()
ROMAZICON ()
RO-15-1788 ()
RO-151788000 ()
FLUMAZEPIL ()
NSC-759193 ()
Flumazenil-d5 ()
P&D ID
PD000330
CAS
78755-81-4
2700278-14-2
Tags
available
drug
Approved by
FDA
First approval
1991
Drug indication
Benzodiazepine overdose
Antagonist (to benzodiazepine)
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Flumazenil, an imidazobenzodiazepine derivative, is a benzodiazepine antagonist. It competitively inhibits the benzodiazepine binding site on the GABA/benzodiazepine receptor complex. Flumazenil is a weak partial agonist in some animal models of activity, but has little or no agonist activity in man.
DESCRIPTION Please note the image of the structure shown here does not specify the position of the carbon isotope. (GtoPdb)
DESCRIPTION Subunit selective nAChR agonist (Tocris Bioactive Compound Library)
DESCRIPTION Benzodiazepine antagonist (Tocriscreen Plus)
DESCRIPTION Benzodiazepine receptor antagonist (LOPAC library)
DESCRIPTION Benzodiazepine antagonist (Tocriscreen Total)
Compound Sets
39
AdooQ Bioactive Compound Library
A10397
Cayman Chemical Bioactives
14252
28529
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL407
ChEMBL Drugs
CHEMBL407
Concise Guide to Pharmacology 2017/18
4192
4367
Concise Guide to Pharmacology 2019/20
4192
4367
Concise Guide to Pharmacology 2021/22
4192
4367
Concise Guide to Pharmacology 2023/24
4192
4367
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB01205
DrugBank Approved Drugs
DB01205
DrugCentral
1195
DrugCentral Approved Drugs
1195
DrugMAP
DMPCG2L
DrugMAP Approved Drugs
DMPCG2L
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101122
EUbOPEN Chemogenomics Library
EUB0000531
Guide to Pharmacology
4192
4367
Ki Database
flumazenil
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL407
Mcule NIBR MoA Box Subset
MCULE-2830706565
MedChem Express Bioactive Compound Library
HY-B0009
NCATS Inxight Approved Drugs
40P7XK9392
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
Flumazenil
TargetMol Bioactive Compound Library
T1240
The Spectrum Collection
Tocris Bioactive Compound Library
1328
Tocriscreen Plus
1328
Tocriscreen Total
ZINC Tool Compounds
ZINC000000001464
External IDs
46
Properties
(calculated by RDKit )
Molecular Weight
303.1
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
1.77
TPSA
64.43
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
7.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
MOA
ionotropic GABA receptor antagonist
Benzodiazepine
GABA(A) BZ Site Receptor Antagonists
benzodiazepine receptor antagonist
Target
GABA-A receptor
anion channel
GABAR
GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ
GABA Receptor
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Neuronal Signaling
Primary Target
GABAA Receptors
Member status
member
Indication
sedative
Recommended Cell Concentration
None
Source data