General
Preferred name
Phylloquinone
Synonyms
PHYTONADIONE [5mM] ()
phytomenadione ()
Phyllohydroquinone ()
PHYTONADIONE ()
Vitamin K1 ()
Phyllohydroquinone, Phylloquinone, Phytomenadione, Phytonadione ()
Vitamin K 1 ()
Phytomenadione ()
Kanavit ()
Aquamephyton ()
Konakion MM ()
Konakion ()
Orakay ()
Fitomenadiona ()
Phylloquinone e-form ()
Konakion MM Paed ()
NSC-270681 ()
Neokay ()
Mephyton ()
Vitamin K1 ()
P&D ID
PD000381
CAS
10485-69-5
84-80-0
79083-00-4
Tags
available
drug
Approved by
FDA
First approval
2000
Drug indication
Vitamin (prothrombogenic)
Bleeding disorder
Vitamin K deficiency
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
54
Properties
(calculated by RDKit )
Molecular Weight
450.35
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
14
Ring Count
2
Aromatic Ring Count
1
cLogP
9.16
TPSA
34.14
Fraction CSP3
0.61
Chiral centers
2.0
Largest ring
6.0
QED
0.26
Structural alerts
1
quinone_A(370)
[!#6&!#1]=[#6]-1-[#6]=,:[#6]-[#6](=[!#6&!#1])-[#6]=,:[#6]-1
PAINS Family A
Related compounds
Custom attributes
(extracted from source data)
Target
GGCX
Osteocalcin
BGLAP, GGCX
Endogenous Metabolite
Vitamin
Member status
member
MOA
Cytochrome P450 CYP4F2 Inhibitors
Vitamin K analogs
Indication
vitamin K deficiency, anticoagulation reversal
Therapeutic Class
Vitamins
Pathway
Metabolic Enzyme/Protease
Source data
