General
Preferred name
ICARIIN
Synonyms
Ieariline ()
Epimedii herba icariin ()
P&D ID
PD000540
CAS
489-32-7
Tags
natural product
drug candidate
available
Drug Status
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Compound Sets
13
AdooQ Bioactive Compound Library
A10464
Cayman Chemical Bioactives
13624
ChEMBL Drugs
CHEMBL553204
Drug Repurposing Hub
DrugBank
DB12052
DrugMAP
DMOJQGT
Mcule NIBR MoA Box Subset
MCULE-1759562501
MedChem Express Bioactive Compound Library
HY-N0014
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
T2855
The Spectrum Collection
External IDs
31
Properties
(calculated by RDKit )
Molecular Weight
676.24
Hydrogen Bond Acceptors
15
Hydrogen Bond Donors
8
Rotatable Bonds
9
Ring Count
5
Aromatic Ring Count
3
cLogP
0.07
TPSA
238.2
Fraction CSP3
0.48
Chiral centers
10.0
Largest ring
6.0
QED
0.14
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Autophagy
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Target
PDE5
PDE5A
Phosphodiesterase (PDE)
PPAR
Member status
member
MOA
Sorbitol dehydrogenase inhibitor
phosphodiesterase inhibitor
Source data