General
Preferred name
SINOMENINE
Synonyms
Cucoline hydrochloride ()
Kukoline hydrochloride ()
Sabianine A hydrochloride ()
Cucoline ()
Kukoline ()
Sinomenine hydrochloride ()
Cucoline, Kukoline ()
Sinomenin ()
P&D ID
PD000544
CAS
6080-33-7
115-53-7
Tags
natural product
drug candidate
available
Drug indication
Arthritis
Drug Status
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
11
AdooQ Bioactive Compound Library
A12221
BOC Sciences Bioactive Compounds
sinomenine-cas-115-53-7-item-84-55068
ChEMBL Drugs
CHEMBL248095
Drug Repurposing Hub
DrugBank
DB16892
DrugMAP
DMYP3KI
MedChem Express Bioactive Compound Library
HY-15122
HY-15122A
ReFrame library
Selleckchem Bioactive Compound Library
Sinomenine(Cucoline)
TargetMol Bioactive Compound Library
T2726
T2921
The Spectrum Collection
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
329.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
1
cLogP
2.02
TPSA
59.0
Fraction CSP3
0.53
Chiral centers
3.0
Largest ring
6.0
QED
0.9
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
NF-??b
NF-??
Apoptosis
Autophagy
GPCR/G protein
Neuronal Signaling
NF-κB
Target
NF-??B
Opioid Receptor
Immunology & Inflammation related
MOA
angiogenesis inhibitor
Source data