General
Preferred name
DOPAMINE
Synonyms
3-HYDROXYTYRAMINE ()
DOPAMINE HYDROCHLORIDE ()
ASL279 ()
Dopamine HCl ()
Dopamine HCl ()
Intropin ()
ASL279, NSC 173182 ()
Dopamine-d4 (hydrochloride) ()
Dopamine (hydrochloride) ()
Dobutamine a ()
Oxytyramine ()
NSC-173182 ()
A-dopamine ()
Medopa ()
Cardiosteril ()
Dopamini hydrochloridum ()
ASL-279 ()
Sabax Dopamin ()
Selectajet ()
Tensamin ()
Inotropin ()
NSC-169105 ()
Dopamin-Natterman ()
Dynatra ()
Dopmin ()
CARDIOSTERIL ()
DOPAMINI HYDROCHLORIDUM ()
DOPMIN ()
INOTROPIN ()
SELECTAJET ()
TENSAMIN ()
P&D ID
PD000596
CAS
4390-27-6
1477-71-0
50444-17-2
51-61-6
203633-19-6
62-31-7
Tags
natural product
drug
endogenous
available
Approved by
FDA
First approval
1974
Drug indication
Hypotension
Adrenergic
Parkinson disease
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ROE It has been reported that about 80% of the drug is excreted in the urine within 24 hours, primarily as HVA and its sulfate and glucuronide conjugates and as 3,4-dihydroxyphenylacetic acid.; A very small portion is excreted unchanged.
DESCRIPTION Dopamine is the precursor to norepinephrine () and epinephrine (). (GtoPdb)
DESCRIPTION Endogenous hormone; agonist at MT1 and MT2 (Tocris Bioactive Compound Library)
DESCRIPTION Endogenous neurotransmitter (LOPAC library)
Cell lines
1
Organisms
5
Compound Sets
35
AdooQ Bioactive Compound Library
A10331
Cayman Chemical Bioactives
36532
21992
36309
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL59
CHEMBL1557
ChEMBL Drugs
CHEMBL59
CHEMBL1557
Concise Guide to Pharmacology 2017/18
940
Concise Guide to Pharmacology 2019/20
940
Concise Guide to Pharmacology 2021/22
940
Concise Guide to Pharmacology 2023/24
940
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00988
DrugBank Approved Drugs
DB00988
DrugCentral
947
DrugCentral Approved Drugs
947
DrugMAP
DMPGUCF
DrugMAP Approved Drugs
DMPGUCF
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS102253
EUbOPEN Chemogenomics Library
Guide to Pharmacology
940
Ki Database
DOPAMINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL59
CHEMBL1557
NCATS Inxight Approved Drugs
VTD58H1Z2X
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Dopamine-hydrochloride-Inotropin
TargetMol Bioactive Compound Library
T1644
The Spectrum Collection
Tocris Bioactive Compound Library
3548
ZINC Tool Compounds
ZINC000000033882
External IDs
83
Properties
(calculated by RDKit )
Molecular Weight
153.08
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
0.6
TPSA
66.48
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
D(3) dopamine receptor
D(1B) dopamine receptor
D(4) dopamine receptor
D(1A) dopamine receptor
D(2) dopamine receptor
Beta-1 adrenergic receptor
5-HT
DA transporter
dopamine
DBH, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR7, SLC6A2, SLC6A3, SLC6A4
Dopamine Receptor
MOA
Dopamine Receptor agonist
Agonist
Pathway
GPCR/G protein
Neuroscience
Primary Target
D1 and D5 Receptors
Indication
ventricular arrhythmias, depression, headache, tremors
Disease Area
cardiology, neurology/psychiatry
Therapeutic Class
Cardiotonic Agents
Recommended Cell Concentration
None
Source data