General
Preferred name
SKF 38393
Synonyms
6-PHENYL-4-AZOBICYCLO[5.4.0]UNDECA-7,9,11-TRIENE-9,10-DIOL ()
(±)-SKF-38393 hydrochloride ()
SKF 38393 hydrobromide ()
(+/-)-SKF-38393 ()
R(+)-SKF-38393 ()
(¡À)-SKF-38393 hydrochloride ()
SKF-38393A ()
(??)-SKF-38393 hydrochloride ()
SKF 38393 hydrochloride ()
SKF 38393 (+) ()
SKF38393 HCl ()
SKF-38393A(¡À)-SKF-38393 hydrochloride ()
SKF-38393 ()
SK& ()
F-38393 ()
SKF 38393 (hydrochloride) ()
SKF 38393 (hydrobromide) ()
NCG-C00093856-01 ()
SK-383933 ()
SK-38393 ()
SK&F-38393 ()
SK&F-383933 ()
P&D ID
PD000629
CAS
62717-42-4
20012-10-6
159795-65-0
67287-49-4
86305-51-3
81633-77-4
Tags
natural product
biased GPCR ligand
drug candidate
available
Drug indication
Type-2 diabetes
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION SKF-38393 appears to be selective for dopamine D1-like receptors, comapred to the D2 receptor . (GtoPdb)
DESCRIPTION D1 dopamine receptor agonist (LOPAC library)
DESCRIPTION Selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker (Tocris Bioactive Compound Library)
DESCRIPTION Selective D1-like agonist (Tocriscreen Total)
DESCRIPTION SKF 38393 hydrobromide is a selective dopamine D1-like receptor partial agonist (Ki = 1, ~ 0.5, ~ 150, ~ 5000 and ~ 1000 nM for D1, D5, D2, D3 and D4 receptors, respectively). (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
2
Compound Sets
20
BiasDB
SKF38393
BOC Sciences Bioactive Compounds
skf-38393-hydrobromide-cas-20012-10-6-item-170593
Cayman Chemical Bioactives
19150
Concise Guide to Pharmacology 2017/18
935
Concise Guide to Pharmacology 2019/20
935
Concise Guide to Pharmacology 2021/22
935
Concise Guide to Pharmacology 2023/24
935
DrugMAP
DMIMJ8Z
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS101074
EUbOPEN Chemogenomics Library
Guide to Pharmacology
935
Ki Database
SKF 38393
SKF 38393 (+)
LOPAC library
MedChem Express Bioactive Compound Library
HY-12520A
ReFrame library
Selleckchem Bioactive Compound Library
skf38393-hcl
TargetMol Bioactive Compound Library
T6988
Tocris Bioactive Compound Library
0922
Tocriscreen Total
External IDs
50
Properties
(calculated by RDKit )
Molecular Weight
255.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
2.38
TPSA
52.49
Fraction CSP3
0.25
Chiral centers
1.0
Largest ring
7.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D1
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
D5 receptor
Dopamine Receptor
Primary Target
D1 and D5 Receptors
MOA
Dopamine Receptor agonist
Agonist
Recommended Cell Concentration
None
Source data