General
Preferred name
RITONAVIR
Synonyms
RTV ()
ABT 538 ()
A 84538 ()
Abbott 84538 ()
Ritonavir (ABT-538) ()
ABT-538,A 84538, RTV, Norvir, Norvir Softgel ()
Ritonavir ()
Ritonavir-d6 ()
ABBOTT-84538 ()
Viriton ()
Ritonavirum ()
ABT-538 ()
Empetus ()
Ritomune ()
Ritovir ()
Norvir ()
NSC-693184 ()
Viekirax ()
A-84538 ()
Ritonavir related compounds mixture ()
P&D ID
PD001134
CAS
155213-67-5
1217720-20-1
Tags
natural product
drug
available
Approved by
PMDA
FDA
EMA
First approval
1996
Drug indication
Human immunodeficiency virus infection
Antiviral
Drug Status
investigational
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ritonavir is an orally bioavailable antiviral that is generally administered in combination with other anti-HIV or anti-HCV drugs. (GtoPdb)
DESCPRITION Ritonavir is a peptidomimetic inhibitor of the HIV-1 protease. Inhibition of HIV protease renders the enzyme incapable of processing the Gag-Pol polyprotein precursor which leads to production of non-infectious immature HIV particles.
DESCRIPTION Potent and selective DDR1 inhibitor; orally bioavailable (Tocris Bioactive Compound Library)
Cell lines
2
Organisms
10
Compound Sets
31
AdooQ Bioactive Compound Library
A10799
Axon Medchem Screening Library
3139
Cayman Chemical Bioactives
13872
25462
ChEMBL Approved Drugs
CHEMBL163
ChEMBL Drugs
CHEMBL163
Concise Guide to Pharmacology 2017/18
8804
Concise Guide to Pharmacology 2019/20
8804
Concise Guide to Pharmacology 2021/22
8804
Concise Guide to Pharmacology 2023/24
8804
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00503
DrugBank Approved Drugs
DB00503
DrugCentral
2391
DrugCentral Approved Drugs
2391
DrugMAP
DMU764S
DrugMAP Approved Drugs
DMU764S
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101528
Guide to Pharmacology
8804
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL163
MedChem Express Bioactive Compound Library
HY-90001
NCATS Inxight Approved Drugs
O3J8G9O825
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Ritonavir
TargetMol Bioactive Compound Library
T1525
The Spectrum Collection
Tocris Bioactive Compound Library
5856
External IDs
53
Properties
(calculated by RDKit )
Molecular Weight
720.31
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
4
Rotatable Bonds
17
Ring Count
4
Aromatic Ring Count
4
cLogP
5.91
TPSA
145.78
Fraction CSP3
0.43
Chiral centers
4.0
Largest ring
6.0
QED
0.11
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Proteases/Proteasome
Anti-infection
Apoptosis
Metabolic Enzyme/Protease
Target
HIV Protease
CYP1A2, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4, CYP3A5, CYP3A7
HIV protease inhibitor
HIV
SARS-CoV
Apoptosis related,COVID-19,HIV Protease,P450 (e.g. CYP17)
Primary Target
Other Proteases
MOA
Inhibitor
HIV Protease inhibitor
Indication
human immunodeficiency virus (HIV-1)
Therapeutic Class
Anti-HIV Agents
Source data