General
Preferred name
TETRANDRINE
Synonyms
NSC-77037£»d-Tetrandrine ()
NSC-77037??d-Tetrandrine ()
Fanchinine ()
Hanfangchin A ()
Sinomenine A ()
(+)-Tetrandrine ()
Tetrandrine (Fanchinine) ()
NSC-77037 ()
d-Tetrandrine ()
ISOTETRANDRINE ()
Tetrandrine (NSC-77037) ()
Fanchinine, d-Tetrandrine ()
FANCHININ ()
P&D ID
PD001239
CAS
518-34-3
23495-89-8
Tags
natural product
drug
nuisance
available
Drug indication
Sarcoma
Colorectal cancer
Drug Status
approved
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tetrandrine is a compound that can be extracted from the Stephania tetrandra vine, or synthesised chemically. It has been demonstrated to act as an inhibitor of multiple ion channels, including two-pore channels 1 and 2 (TPC1/2), and L- and T-type calcium channels . The TPC calcium channels appear to be important for Ebola virus infection of host cells, and in vitro either ablation of TPC expression or tetrandrine-mediated inhibition of TPC channels reduces Ebola infection (IC50 55 nM) .
SARS-CoV-2 infection (COVID-19): Tetrandrine is being studied in clinical trial for potential to treat COVID-19. The biological and pharmacological rationale for this use was reviewed in . (GtoPdb)
SARS-CoV-2 infection (COVID-19): Tetrandrine is being studied in clinical trial for potential to treat COVID-19. The biological and pharmacological rationale for this use was reviewed in . (GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
17
Organisms
2
Compound Sets
12
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
622.3
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
8
Aromatic Ring Count
4
cLogP
7.16
TPSA
61.86
Fraction CSP3
0.37
Chiral centers
2.0
Largest ring
18.0
QED
0.24
Structural alerts
1
Nonspecific/NOS
IMP
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Anti-infection
Neuronal Signaling
Target
Calcium Channel
SLC6A3
Parasite
Potassium Channel
MOA
Calcium Channel inhibitor
calcium channel blocker
Source data
