General
Preferred name
DAPHNETIN
Synonyms
7,8-Dihydroxycoumarin ()
Daphnetol ()
TCMDC-125839 ()
P&D ID
PD001265
CAS
486-35-1
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Protein kinase (PK) inhibitor (LOPAC library)
Cell lines
1
Organisms
2
Compound Sets
7
AdooQ Bioactive Compound Library
A10286
Cayman Chemical Bioactives
20826
Drug Repurposing Hub
LOPAC library
MedChem Express Bioactive Compound Library
HY-N0281
Selleckchem Bioactive Compound Library
Daphnetin
TargetMol Bioactive Compound Library
T2851
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
178.03
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
2
cLogP
1.2
TPSA
70.67
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
PK
Pathway
Angiogenesis
Cytoskeletal Signaling
GPCR/G protein
JAK/STAT Signaling
Tyrosine Kinase/Adaptors
Anti-infection
Apoptosis
Autophagy
Cell Cycle/DNA Damage
Epigenetics
Immunology/Inflammation
Metabolic Enzyme/Protease
NF-κB
PI3K/Akt/mTOR
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
TGF-beta/Smad
Target
EGFR
PKA
PKC
Akt
AMPK
Bcl-2 Family
Caspase
MTOR
Parasite
PARP
Reactive Oxygen Species
EGFR,PKA,PKC
MOA
protein kinase inhibitor
Source data