General
Preferred name
FISETIN
Synonyms
Fisetin (Fustel) ()
3,7,3',4'-TETRAHYDROXYFLAVONE ()
Fisetin-d5 ()
C.i. natural brown 1 ()
NSC-656275 ()
C.i. 75620 ()
5-desoxyquercetin ()
NSC-407010 ()
Fisidenolon 1521 ()
P&D ID
PD001338
CAS
528-48-3
2909407-29-8
Tags
natural product
drug candidate
nuisance
obsolete probe
available
Drug indication
Discovery agent
Drug Status
investigational
experimental
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Fisetin is a plant flavonoid. It is used as an ingredient in dietary supplements. It has been investigated for potential anti-inflammatory and senolytic-like actions . It is a more potent senolytic than .
(GtoPdb)
DESCRIPTION
Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1); active in vivo
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
9
Organisms
4
Compound Sets
17
AdooQ Bioactive Compound Library
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NIH Mechanistic Set
Nuisance compounds in cellular assays
Obsolete Compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
40
Molecular Weight
286.05
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
4
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
2.28
TPSA
111.13
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.51
Structural alerts
4
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Nonspecific/NOS
Flavonoid
Nuisance compounds in cellular assays
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Pathway
Chromatin/Epigenetic
DNA Damage/DNA Repair
Apoptosis
Cell Cycle/DNA Damage
Epigenetics
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Target
SIRT
CDK6, FASN
PPAR
Sirtuin
TNF Receptor
Primary Target
Antioxidants
MOA
Aurora Kinase inhibitor
Source data
