General
Preferred name
RESVERATROL
Synonyms
ML027 Analog ()
trans-Resveratrol ()
SRT 501 ()
SRT501 ()
resveratrol, Royalmount ()
Resveratrol (SRT501) ()
trans-Resveratrol,SRT501 ()
trans-Resveratrol-d4 ()
(E)-resveratrol ()
Biofort ()
3,5,4'-Trihydroxy-trans-stilbene ()
BIA-6-512 ()
Cuspidatin ()
Polygonin ()
Ca 1201 ()
Resveratrol p 5 ()
(e)-5-(p-hydroxystyryl)resorcinol ()
Resveratrol(e)-form ()
Melinjo resveratrol 20 ()
BIA 6-512 ()
Srt 501m ()
Resvida ()
NSC-327430 ()
P&D ID
PD001353
CAS
501-36-0
31100-06-8
1089051-56-8
Tags
available
probe
natural product
drug candidate
nuisance
obsolete probe
Drug indication
Systemic sclerosis
Rheumatoid arthritis
Giant cell arteritis
Colorectal cancer
Drug Status
investigational
Max Phase
3.0
Probe info
Probe selectivity
protein-selective
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
2
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Resveratrol is a natural product found in the skins of grapes and some other berries used predominantly as an antioxidant dietery supplement . The compound exists as a mixture of trans- (shown here) and cis- (PubChem CID 1548910) conformations. Resveratrol has been investigated for its various roles in complex biological processes . It has some activity as a cyclooxygenase inhibitor/antiinflammatory agent.
(GtoPdb)
DESCRIPTION
Cyclooxygenase-2 (COX-2) inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity
(LOPAC library)
DESCRIPTION
Cyclooxygenase inhibitor
(Tocriscreen Total)
DESCRIPTION
Cyclooxygenase inhibitor
(Tocriscreen Plus)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
55
Organisms
6
Compound Sets
26
AdooQ Bioactive Compound Library
ChEMBL Drugs
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
Guide to Pharmacology
LINCS compound set
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
MLSMR Probes +
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
Nuisance compounds in cellular assays
Obsolete Compounds
Probe Miner (suitable probes)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
56
Molecular Weight
228.08
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
2.97
TPSA
60.69
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
2
historic compounds (Chemical Probes.org)
Obsolete
Nonspecific/NOS
Resveratrols
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Classification
probe analog
Target Type
Enzymes
Selectivity
COX
Pathway
NF-¦ÊB
Chromatin/Epigenetic
Immunology/Inflammation
DNA Damage/DNA Repair
Metabolism
NF-??b
Neuroscience
NF-??
Anti-infection
Apoptosis
Autophagy
Cell Cycle/DNA Damage
Epigenetics
NF-κB
Target
COX-1
COX-2
DNA polymerase ??
IKK??
LOX
Quinone reductase 2
SIRT1
SIRT2
CSNK2A1, NQO2, PTGS1, PTGS2
antibiotic
Bacterial
Fungal
IKK
Keap1-Nrf2
Mitophagy
AMPK,Apoptosis related,Autophagy,COX,ERK,I¦ÊB/IKK,JNK,Lipoxygenase,Mitophagy,Sirtuin,Src,STAT
Primary Target
Cyclooxygenases
MOA
DNA/RNA Synthesis
I¦ÊB/IKK
Lipoxygenase
NADPH
Sirtuin
Inhibitor
Anti-inflammatory
Antioxidant
cytochrome P450 inhibitor, SIRT activator
Member status
member
Source data
