General
Preferred name
CYCLOHEXIMIDE
Synonyms
CHX ()
Cicloheximide ()
Actidione ()
Naramycin A ()
U-4527 ()
GNF-Pf-5118 ()
TCMDC-125838 ()
NSC-171 ()
NSC-185 ()
P&D ID
PD001378
CAS
66-81-9
1154-57-0
Tags
natural product
drug candidate
nuisance
available
Drug indication
Discovery agent
Antipsoriatic
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cycloheximide is an antifungal antibiotic. It is known to inhibit the FKBP prolyl isomerase 1A (a.k.a. FKBP12) . (GtoPdb)
DESCRIPTION Antifibrotic agent; regulates cytokine levels in vivo (Tocris Bioactive Compound Library)
Cell lines
23
Organisms
8
Compound Sets
17
AdooQ Bioactive Compound Library
A10036
Cayman Chemical Bioactives
14126
ChEMBL Drugs
CHEMBL123292
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMGDA3C
EU-OPENSCREEN Bioactive Compound Library
EOS101804
Guide to Pharmacology
5433
JUMP-Target 1 Compound Set
6197
LINCS compound set
10484-999
Novartis Chemogenetic Library (NIBR MoA Box)
Nuisance compounds in cellular assays
Prestwick Chemical Library
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
ReFrame library
The Spectrum Collection
Tocris Bioactive Compound Library
0970
External IDs
40
Properties
(calculated by RDKit )
Molecular Weight
281.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
0
cLogP
1.04
TPSA
83.47
Fraction CSP3
0.8
Chiral centers
4.0
Largest ring
6.0
QED
0.76
Structural alerts
1
Protein disruption
Translation inhibition
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Primary Target
DNA, RNA and Protein Synthesis
MOA
Inhibitor
Translation inhibitor
Glycogen Synthase Kinase 3 beta (GSK-3beta
tau Protein Kinase I) Inhibitors
"Translation inhibitor
tau Protein Kinase I) Inhibitors"
protein synthesis inhibitor
Target
Ferroptosis
RPL3
Pathway
Apoptosis
Member status
member
Cellular injury category
Miscellaneous
Source data