General
Preferred name
OFLOXACIN
Synonyms
LEVOFLOXACIN ()
Hoe-280 ()
DL8280 ()
Floxin ()
Tarivid ()
Oxaldin ()
Ofloxacin (DL8280) ()
Tarivid 400 ()
HOE 280 ()
DL-8280 ()
J01MA01 ()
Visiren ()
NSC-727071 ()
Floxin Otic ()
Exocin ()
NSC-758178 ()
Ocuflox ()
Ofloxacine ()
Ofloxacino ()
Tarivid I.V. ()
Ofloxacin-d8 (hydrochloride) ()
P&D ID
PD001409
CAS
82419-36-1
2930288-81-4
Tags
available
drug
Approved by
FDA
First approval
1990
Drug indication
Antibacterial
Bacterial infection
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ROE
Ofloxacin is mainly eliminated by renal excretion, where between 65% and 80% of an administered oral dose of ofloxacin is excreted unchanged via urine within 48 hours of dosing. About 4-8% of an ofloxacin dose is excreted in the feces and the drug is minimally subject to biliary excretion.
DESCRIPTION
Ofloxacin is a second generation fluoroquinolone antibacterial.
(GtoPdb)
DESCRIPTION
Fluorinated quinolone antibacterial; interferes with DNA synthesis
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
5
Compound Sets
25
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
55
Molecular Weight
361.14
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
1.54
TPSA
75.01
Fraction CSP3
0.44
Chiral centers
1.0
Largest ring
6.0
QED
0.87
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
DNA Synthesis
Pathway
DNA Damage/DNA Repair
Anti-infection
Metabolic Enzyme/Protease
Target
Topo
antibiotic
Bacterial
Endogenous Metabolite
Orthopoxvirus
Topoisomerase
Therapeutic Class
Antibiotics
Source data
