General
Preferred name
OROTIC ACID
Synonyms
Vitamin B13 ()
6-Carboxyuracil ()
2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrate ()
Orotic acid (6-Carboxyuracil), 6-Carboxyuracil, Orodin, Oropur, Orotonin, Orotonsan ()
Orotate ()
Orotic acid (hydrate) ()
Orotic acid (6-Carboxyuracil) ()
2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate ()
Orotic Acid Monohydrate ()
Zinc orotate ()
Animal galactose factor ()
Whey factor ()
NSC-9791 ()
Oropur ()
Orotyl ()
Acido orotico ()
Acide orotique ()
P&D ID
PD001471
CAS
68460-00-4
60388-02-5
68399-76-8
65-86-1
73-97-2
50887-69-9
Tags
available
drug candidate
drug
Drug indication
Discovery agent
Drug Status
experimental
approved
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Orotic acid has been assigned an INN in its own right and is also a component of the INN-assigned compound orazamide. (GtoPdb)
DESCRIPTION Orotic acid is a heterocyclic compound and an acid. It is manufactured in the body via a mitochondrial enzyme, dihydroorotate dehydrogenase, or a cytoplasmic enzyme of pyrimidine synthesis pathway. (BOC Sciences Bioactive Compounds)
Compound Sets
21
AdooQ Bioactive Compound Library
A10677
BOC Sciences Bioactive Compounds
orotic-acid-cas-65-86-1-item-84-74640
ChEMBL Drugs
CHEMBL1235017
Concise Guide to Pharmacology 2017/18
4690
Concise Guide to Pharmacology 2019/20
4690
Concise Guide to Pharmacology 2021/22
4690
Concise Guide to Pharmacology 2023/24
4690
Drug Repurposing Hub
DrugBank
DB02262
DB15720
DrugCentral
3402
DrugCentral Approved Drugs
3402
DrugMAP
DMP6BSH
DMMB29S
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
4690
MedChem Express Bioactive Compound Library
HY-N0157
HY-W016812
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
Orotic-acid(6-Carboxyuracil)
2-6-dioxo-1-2-3-6-tetrahydropyrimidine-4-carboxylic-acid-hydrate
TargetMol Bioactive Compound Library
T0746
The Spectrum Collection
External IDs
78
Properties
(calculated by RDKit )
Molecular Weight
156.02
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
-1.24
TPSA
103.02
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Target
DHOase
Apoptosis
DHODH
Endogenous Metabolite
Nucleoside antimetabolite/analog
MOA
Dehydrogenase
Source data