General
Preferred name
FAMOTIDINE
Synonyms
MK-208 ()
YM 11170 ()
MK208 ()
Famotidine-13C-d3 ()
Ganor ()
L 643341 ()
Pepcid preservative free ()
Pepcid ()
YM-11170 ()
Pepcid Rpd ()
Pepdul ()
Lecedil ()
Fluxid ()
Amfamox ()
Famotidine preservative free ()
Pepdine ()
Famotidine preservative free (pharmacy bulk) ()
Gastridin ()
Muclox ()
Famodil ()
Fadul ()
Pepcidac ()
Famosan ()
Motiax ()
NSC-757810 ()
Gastropen ()
Pepcid Ac ()
Famoxal ()
AMFAMOX ()
FADUL ()
FAMODIL ()
FAMOSAN ()
FAMOTIDINE PRESERVATIVE FREE ()
FAMOTIDINE PRESERVATIVE FREE (PHARMACY BULK) ()
FAMOXAL ()
FLUXID ()
GANOR ()
GASTRIDIN ()
GASTROPEN ()
LECEDIL ()
MOTIAX ()
MUCLOX ()
PEPCID ()
PEPCID AC ()
PEPCID PRESERVATIVE FREE ()
PEPCID RPD ()
PEPCIDAC ()
PEPDINE ()
PEPDUL ()
P&D ID
PD001511
CAS
76824-35-6
2744683-81-4
Tags
drug
biased GPCR ligand
natural product
available
Approved by
FDA
First approval
1986
Drug indication
Antagonist (to histamine-H2 receptors)
Peptic ulcer
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCPRITION A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
DESCRIPTION Famotidine is a histamine H2 receptor antagonist. The drug is poorly soluble in the low pH of the stomach so suffers from poor bioavailability. Low dose (10-20 mg) famotidine is available over-the-counter in some countries. Marketing of a combination of famotidine with antacids magnesium hydroxide and calcium carbonate (Pepcidtwo®) has been officially discontinued in the UK (2015). (GtoPdb)
DESCRIPTION Potent, selective and competitive non-peptide NPY Y2 receptor antagonist; active in vivo (Tocris Bioactive Compound Library)
DESCRIPTION H2 Histamine receptor antagonist (LOPAC library)
Compound Sets
31
BiasDB
Famotidine
Cayman Chemical Bioactives
23828
31493
ChEMBL Approved Drugs
CHEMBL902
ChEMBL Drugs
CHEMBL902
Concise Guide to Pharmacology 2023/24
7074
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00927
DrugBank Approved Drugs
DB00927
DrugCentral
1129
DrugCentral Approved Drugs
1129
DrugMAP
DMRL3AB
DrugMAP Approved Drugs
DMRL3AB
DrugMatrix
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
Guide to Pharmacology
7074
Ki Database
YM 11170
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL902
MedChem Express Bioactive Compound Library
HY-B0377
NCATS Inxight Approved Drugs
5QZO15J2Z8
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
famotidine-pepcid
TargetMol Bioactive Compound Library
T1627
The Spectrum Collection
Tocris Bioactive Compound Library
7290
ZINC Tool Compounds
ZINC000001530636
External IDs
63
Properties
(calculated by RDKit )
Molecular Weight
337.04
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
4
Rotatable Bonds
7
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.77
TPSA
175.83
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
5.0
QED
0.29
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H2
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Target
H2 receptor
HRH2
Histamine Receptor
Primary Target
Histamine H2 Receptors
MOA
Inverse Agonist
Histamine Receptor antagonist
Indication
heartburn
Therapeutic Class
Antiulcer Agents
Recommended Cell Concentration
None
Source data