General
Preferred name
PIPERINE
Synonyms
1-Piperoylpiperidine ()
Bioperine ()
(2E,4E)-5-(1,3-dioxaindan-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one ()
NSC-21727 ()
FEMA NO. 2909 ()
P&D ID
PD001540
CAS
94-62-2
7780-20-3
147030-08-8
Tags
natural product
drug candidate
available
Drug indication
Vitiligo
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Cell lines
9
Organisms
3
Compound Sets
17
AdooQ Bioactive Compound Library
A10734
Cayman Chemical Bioactives
11750
ChEMBL Drugs
CHEMBL43185
Concise Guide to Pharmacology 2019/20
2489
Concise Guide to Pharmacology 2021/22
2489
Concise Guide to Pharmacology 2023/24
2489
Drug Repurposing Hub
DrugBank
DB12582
DrugMAP
DMYEAB1
Guide to Pharmacology
2489
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL43185
MedChem Express Bioactive Compound Library
HY-N0144
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
Piperine(1-Piperoylpiperidine)
TargetMol Bioactive Compound Library
T3002
The Spectrum Collection
External IDs
40
Properties
(calculated by RDKit )
Molecular Weight
285.14
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
1
cLogP
3.0
TPSA
38.77
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Metabolism
Autophagy
Metabolic Enzyme/Protease
Target
P-gp?(P-glycoprotein)
CYP3A4
MAOA, MAOB, TRPV1
Endogenous Metabolite
P-glycoprotein
P450 (e.g. CYP17)
Member status
member
MOA
ACAT Inhibitors
MAO-A Inhibitors
MAO-B Inhibitors
monoamine oxidase inhibitor
Source data