General
Preferred name
BUTAMBEN
Synonyms
ABBOTT-34842 ()
Butyl aminobenzoate ()
Butyl 4-aminobenzoate ()
butamben, Jazz ()
P-aminobenzoic acid butyl ester ()
NSC-128464 ()
Butyl p-aminobenzoate ()
Butyl paba ()
BUTAMBEN PICRATE ()
P&D ID
PD001588
CAS
94-25-7
577-48-0
Tags
available
drug
Approved by
FDA
Drug Status
approved
withdrawn
Max Phase
4.0
Drug indication
Anesthetic (topical)
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Butyl 4-aminobenzoate acts as a long-duration local anesthetic. It aids in treatment of chronic pain. It is also known to induce anti-nociception effects in subjects. It has been listed. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
20
BOC Sciences Bioactive Compounds
butyl-4-aminobenzoate-cas-94-25-7-item-79919
ChEMBL Approved Drugs
CHEMBL127516
CHEMBL3142541
ChEMBL Drugs
CHEMBL127516
CHEMBL3142541
Drug Repurposing Hub
DrugBank
DB11148
DrugBank Approved Drugs
DB11148
DrugCentral
3051
DrugCentral Approved Drugs
3051
DrugMatrix
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-B1430
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2FDXOXEWT42N
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
butamben
TargetMol Bioactive Compound Library
T0916
The Spectrum Collection
Withdrawn 2.0
w63
External IDs
53
Properties
(calculated by RDKit )
Molecular Weight
193.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
2.23
TPSA
52.32
Fraction CSP3
0.36
Chiral centers
0.0
Largest ring
6.0
QED
0.45
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
Potassium Channel inhibitor
Calcium Channel
Potassium Channel
Sodium Channel
MOA
Sodium Channel blocker
ATC
N
Toxicity type
dermatological
Solubility
10 mM in DMSO
Source data