General
Preferred name
kynurenic acid
Synonyms
Kynurenic acid (sodium) ()
Kynurenate ()
Quinurenic acid|Kynurenate ()
Kynurenic acid sodium salt ()
NSC 58973 ()
Transtorine (Kynurenic acid) ()
TRANSTORINE ()
1,4-Dihydro-4-oxoquinoline-2-carboxylic acid ()
Quinurenic acid, Kynurenate ()
Kynurenic acid, Quinurenic acid ()
Kynurenic Acid (hydrate) ()
Kynurenic Acid-d5 ()
Kynurenic Acid ()
Quinurenic acid ()
P&D ID
PD001631
CAS
492-27-3
2439-02-3
13593-94-7
345909-35-5
350820-13-2
Tags
available
natural product
drug candidate
endogenous
Drug indication
Discovery agent
Drug Status
investigational
Max Phase
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Kynurenic acid is a by-product of the kynurenine pathway, the main route for the non-protein metabolism (catabolism) of tryptophan . (GtoPdb)
DESCRIPTION Endogenous NMDA agonist and transmitter candidate (Tocris Bioactive Compound Library)
DESCRIPTION Potent NMDA antagonist, acts at glycine site; sodium salt of 5,7-Dichlorokynurenic acid (Tocris Bioactive Compound Library)
DESCRIPTION Broad spectrum EAA antagonist (Tocriscreen Plus)
DESCRIPTION Excitatory amino acid receptor antagonist; blocks kainic acid-induced neurotoxicity; metabolite of tryptophan (LOPAC library)
DESCRIPTION Broad spectrum EAA antagonist (Tocriscreen Total)
DESCRIPTION Kynurenic acid sodium salt is the sodium form of kynurenic acid, which is a broad spectrum EAA antagonist. (BOC Sciences Bioactive Compounds)
DESCRIPTION Kynurenic acid is a product of L-Tryptophan metabolism. It is a non-selective antagonist at NMDA and AMPA/kainate receptors. It could block kainic acid neurotoxicity. It has neruoactive activity having anticonvulsant and antiexcitotoxic properties. (BOC Sciences Bioactive Compounds)
Compound Sets
25
BOC Sciences Bioactive Compounds
kynurenic-acid-cas-492-27-3-item-93040
kynurenic-acid-sodium-salt-cas-2439-02-3-item-169585
Cayman Chemical Bioactives
16792
36306
ChEMBL Drugs
CHEMBL299155
Concise Guide to Pharmacology 2017/18
2918
Concise Guide to Pharmacology 2019/20
2918
Concise Guide to Pharmacology 2021/22
2918
Concise Guide to Pharmacology 2023/24
2918
Drug Repurposing Hub
DrugBank
DB11937
DrugMAP
DMP4T87
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101762
Guide to Pharmacology
2918
Ki Database
Kynurenate
LOPAC library
MedChem Express Bioactive Compound Library
HY-100806
HY-W110662
HY-107512
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
1-4-dihydro-4-oxoquinoline-2-carboxylic-acid
kynurenic-acid
The Spectrum Collection
Tocris Bioactive Compound Library
0223
3694
Tocriscreen Plus
0223
Tocriscreen Total
External IDs
58
Properties
(calculated by RDKit )
Molecular Weight
189.04
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
2
cLogP
1.64
TPSA
70.42
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Selectivity
NMDA-Glycine
Pathway
Neuronal Signaling
GPCR/G protein
Immunology/Inflammation
Membrane Transporter/Ion Channel
Apoptosis
Metabolic Enzyme/Protease
Anti-infection
Target
CXCR
iGluR
¦Á7 nicotinic acetylcholine receptor
glutamate receptors
GPR35, GRIN1, GRIN2A, GRIN2B
Endogenous Metabolite
GPR35
Bacterial
NMDAR
NMDAR/ GluR/AChR
Primary Target
Non-selective Ionotropic Glutamate
MOA
AChR antagonist
GluR antagonist
Antagonist
NMDA Antagonists
AMPA Receptor Modulators
a7 nicotinic acetylcholine receptor Inhibitor
glutamate receptor antagonist
Member status
member
Source data