General
Preferred name
THIABENDAZOLE
Synonyms
Tiabendazole ()
2-(4-Thiazolyl)benzimidazole ()
THIABENDAZOLE148-79-8 ()
E233 ()
Lombristop ()
Thiabenzole ()
Nemapan ()
NSC-90507 ()
MK-360 ()
NSC-525040 ()
Mintezol ()
Equizole ()
Pitrizet ()
Omnizole ()
Minzolum ()
P&D ID
PD001733
CAS
148-79-8
123242-33-1
Tags
natural product
drug
available
Approved by
FDA
First approval
1967
Drug indication
Dutch elm disease
Anthelmintic
Helminth infection
Drug Status
withdrawn
approved
vet_approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tiabendazole is a fungicide and parasiticide with potential anti-angiogenic (or vascular disrupting) action .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
2
Compound Sets
26
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
201.04
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
2.69
TPSA
41.57
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Unknown molecular target
angiogenesis inhibitor
Target
Tubulin
Tubulin ??
Caspase
CDK
Interleukin Related
MDM-2/p53
Mitochondrial Metabolism
Parasite
VEGFR
P450 (e.g. CYP17)
Pathway
Cytoskeletal Signaling
Anti-infection
Apoptosis
Cell Cycle/DNA Damage
Immunology/Inflammation
Metabolic Enzyme/Protease
Protein Tyrosine Kinase/RTK
Indication
gastrointestinal roundworms, hookworm
ATC
D01AC06
P02CA02
Therapeutic Class
Antinematodal Agents
Source data
