General
Preferred name
SULFAPYRIDINE
Synonyms
2-Sulfapyridine ()
Sulfidin ()
Sulfidine ()
NSC-4753 ()
Concord 693 ()
NSC-41791 ()
Coccoclase ()
Sulfanilamidopyridine ()
Sulphapyridine ()
Eubasin ()
Piridazol ()
Dagenan ()
Sodium sulfapyridine ()
SULFAPYRIDINE SODIUM ()
P&D ID
PD001745
CAS
144-83-2
127-57-1
Tags
natural product
drug
drug candidate
available
Approved by
FDA
First approval
1939
Drug indication
Dermatitis herpetiformis
Suppressant (dermatitis herpetiformis)
Drug Status
withdrawn
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Sulfapyridine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid by means of processing the substrate para-aminobenzoic acid (PABA). Dihydropteroate synthetase activity is vital in the synthesis of folate, and folate is required for cells to make nucleic acids, such as DNA or RNA. So if DNA molecules cannot be built, the cell cannot divide.;
DESCRIPTION
Sulfapyridine is a sulfonamide compound that was used clinically as an antibacterial agent but is now used principally as an anti-inflammatory drug.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
20
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
249.06
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
1.46
TPSA
85.08
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Autophagy
Anti-infection
Target
DHPS
antibiotic
Bacterial
Indication
gram-negative bacterial infections, gram-positive bacterial infections
MOA
PABA antagonist
ATC
J01EB04
Therapeutic Class
Dermatologic Agents
Source data
