General
Preferred name
SALICYLIC ACID
Synonyms
Salcolex ()
2-Hydroxybenzoic acid ()
salicylic-acid ()
Salicyclic acid ()
salicylic acid, Orenova ()
Salicylate ()
Salicylic Acid-d4 ()
Pyralvex ()
Duofilm ()
Compound V ()
Bazuka ()
Phytocil ()
Phytex ()
Acnisal ()
Phiso-Clear ()
Jadit ()
K-557 ()
Toepedo ()
Keralyt ()
2-Hydroxy-benzoic acid ()
NSC-180 ()
Thwart ()
Lamivudine related compound salicylic acid ()
Posalfilin ()
Cuplex Verruca ()
Noxacorn ()
Verrugon ()
Gppe Paint ()
Erytex ()
Compound W ()
Wartex ()
Freezone ()
Salactol ()
Occlusal ()
Salicylic acid rs ()
Metanium ()
Lamivudine impurity, salicylic acid- ()
Salatac ()
FEMA NO. 3985 ()
Necol ()
Edinburgh ()
P&D ID
PD001758
CAS
69-72-7
63-36-5
78646-17-0
Tags
available
natural product
drug
obsolete probe
First approval
1898
Drug indication
Keratolytic
Seborrhoeic dermatitis
Drug Status
investigational
vet_approved
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Salicylic acid directly irreversibly inhibits COX-1 and COX-2 to decrease conversion of arachidonic acid to precursors of prostaglandins and thromboxanes. Salicylate's use in rheumatic diseases is due to it's analgesic and anti-inflammatory activity. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Salicylic acid allows cells of the epidermis to more readily slough off. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid competitively inhibits oxidation of uridine-5-diphosphoglucose (UDPG) with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. It also competitively inhibits the transferring of the glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to a phenolic acceptor. Inhibition of mucopoly saccharide synthesis is likely responsible for the slowing of wound healing with salicylates.
DESCRIPTION
Chemically, salicylic acid is a monohydroxybenzoic acid, a type of phenolic acid and a beta hydroxy acid. It was oridinally isolated from the inner bark of the willow tree. Clinically, it is an important active metabolite of .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
29
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
JUMP-Target 1 Compound Set
Ki Database
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
Obsolete Compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
75
Molecular Weight
138.03
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
1.09
TPSA
57.53
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.61
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Pathway
Immunology/Inflammation
Neuroscience
Apoptosis
Autophagy
Metabolic Enzyme/Protease
Target
COX
AKR1C1, ASIC3, PTGS1, PTGS2
AKR1C1
Endogenous Metabolite
Mitophagy
Indication
acne vulgaris (AV), fever, pain relief
Disease Area
dermatology, endocrinology, neurology/psychiatry
MOA
cyclooxygenase inhibitor, prostanoid receptor antagonist
Therapeutic Class
Antiinflammatory Agents
Source data
