General
Preferred name
RESERPINE
Synonyms
Serpalan ()
Serpasil ()
Serpivite ()
Reserpine (hydrochloride) ()
Reserpinum ()
Serpanray ()
Hiserpia ()
Rau-Sed ()
Serpate ()
NSC-237659 ()
Apoplon ()
NSC-59272 ()
ENT-50146 ()
Reserpina ()
Sandril ()
P&D ID
PD001766
CAS
50-55-5
1407-38-1
1263-94-1
16994-56-2
Tags
available
drug
Approved by
FDA
First approval
1960
1955
Drug indication
Antihypertensive
Hypertension
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Reserpine irreversibly blocks the vesicular monoamine transporter (VMAT; gene symbols SLC18A1 and SLC18A2), to bring about depletion of monoamine neurotransmitters at synapses. (GtoPdb)
DESCRIPTION GABA uptake inhibitor; moderately BGT-1 selective (Tocris Bioactive Compound Library)
DESCRIPTION Inhibits vesicular catecholine and serotonin uptake. (LOPAC library)
DESCRIPTION Inhibitor of vesicular monoamine transport (Tocriscreen Total)
DESCRIPTION Reserpine is an inhibitor of multidrug efflux pumps, used as an antipsychotic and antihypertensive drug. (BOC Sciences Bioactive Compounds)
Cell lines
3
Organisms
3
Compound Sets
32
BOC Sciences Bioactive Compounds
reserpine-cas-50-55-5-item-84-69890
Cayman Chemical Bioactives
16474
ChEMBL Approved Drugs
CHEMBL772
ChEMBL Drugs
CHEMBL772
Concise Guide to Pharmacology 2017/18
4823
Concise Guide to Pharmacology 2019/20
4823
Concise Guide to Pharmacology 2021/22
4823
Concise Guide to Pharmacology 2023/24
4823
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00206
DrugBank Approved Drugs
DB00206
DrugCentral
2370
DrugCentral Approved Drugs
2370
DrugMAP
DM6VM38
DrugMAP Approved Drugs
DM6VM38
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101211
Guide to Pharmacology
4823
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL772
MedChem Express Bioactive Compound Library
HY-N0480
HY-N0480A
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Reserpine
TargetMol Bioactive Compound Library
T0791
The Spectrum Collection
Tocris Bioactive Compound Library
2742
Tocriscreen Total
ZINC Tool Compounds
ZINC000003938746
External IDs
53
Properties
(calculated by RDKit )
Molecular Weight
608.27
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
6
Aromatic Ring Count
3
cLogP
4.17
TPSA
117.78
Fraction CSP3
0.52
Chiral centers
6.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Uptake
Pathway
Immunology/Inflammation
Membrane Transporter/Ion Channel
Autophagy
Target
MRP1
SVAT
Bile salt export pump
SLC18A1, SLC18A2
Monoamine transporter
VMAT
Primary Target
Vesicular Monoamine Transporters
MOA
Inhibitor
Norepinephrine Uptake Inhibitor
Vesicular Monoamine Transporter 2 (VMAT2) Inhibitors
vesicular monoamine transporter inhibitor
Member status
member
Indication
hypertension
Therapeutic Class
Antihypertensive Agents
Source data