General
Preferred name
PHENYLBUTAZONE
Synonyms
Clofezone ()
Butazolidine ()
Phenylbutazone ()
Phenylbutazone-d9 ()
Diphebuzol ()
Butaject ()
Bizolin ()
Zolaphen ()
Tevcodyne ()
Equiphar ()
Fenibutol ()
Mepha-butazon ()
Antadol ()
Robizone-v ()
Ecobutazone ()
Butapirazol ()
Butoz ()
Artrizin ()
Fenibutazona ()
Flexazone ()
Phenyzene ()
Butacote ()
R-3-ZON ()
Butazolidin ()
Ambene ()
Uzone ()
G-13871 ()
Azolid ()
Buzon ()
Diphenylbutazone ()
Shigrodin ()
Pro-Bute ()
Elmedal ()
Phebuzine ()
Butadion ()
Intrabutazone ()
Intrazone ()
Butadiona ()
Butatron ()
Equipalazone ()
NSC-25134 ()
Exrheudon n ()
Fenylbutazon ()
P&D ID
PD001804
CAS
50-33-9
4297-92-1
1189479-75-1
Tags
natural product
drug
available
Approved by
FDA
First approval
1980
Drug indication
Chronic pain
Antirheumatic
Drug Status
withdrawn
approved
vet_approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Phenylbutazone was historically used as a nonsteroidal anti-inflammatory drug (NSAID). Although no longer approved for use in humans, this compound is widely used in animals to reduce muscular damage and inflammation. More recently, phenylbutazone, or 'bute', found notoriety as an illegal contaminant found in some meat samples tested in the European horse meat scandal of 2013. The UK Foods Standards Agency issued this statement regarding bute contamination. (GtoPdb)
DESCRIPTION Anti-inflammatory; substrate for prostaglandin peroxidase (LOPAC library)
Cell lines
1
Organisms
1
Compound Sets
27
AdooQ Bioactive Compound Library
A10720
Cayman Chemical Bioactives
70400
33978
ChEMBL Approved Drugs
CHEMBL101
ChEMBL Drugs
CHEMBL101
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00812
DrugBank Approved Drugs
DB00812
DrugCentral
2145
DrugCentral Approved Drugs
2145
DrugMAP
DMAYL0T
DrugMAP Approved Drugs
DMAYL0T
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
7270
JUMP-Target 1 Compound Set
4781
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL101
MedChem Express Bioactive Compound Library
HY-B0230
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Phenylbutazone(Butazolidin)
TargetMol Bioactive Compound Library
T1432
The Spectrum Collection
Withdrawn 2.0
w149
ZINC Tool Compounds
ZINC000100004227
External IDs
43
Properties
(calculated by RDKit )
Molecular Weight
308.15
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
3.79
TPSA
40.62
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
1
keto_keto_beta_B(12)
[#6;X4]-1-[#6](=[#8])-[#7]-[#7]-[#6]-1=[#8]
PAINS Family C
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Prostaglandin peroxidase
Pathway
Immunology/Inflammation
Neuroscience
Target
COX
PTGIS, PTGS1, PTGS2
PTGIS
Immunology & Inflammation related
MOA
cyclooxygenase inhibitor, prostanoid receptor antagonist
ATC
M01AA01
Toxicity type
hematological
Therapeutic Class
Analgesics
Source data