General
Preferred name
NIACIN
Synonyms
nicotinic acid ()
Vitamin B3 ()
Nicotinic Acid59-67-6 ()
Niaspan Er ()
Niaspan Titration Starter Pack ()
Acide nicotinique ()
NSC-169454 ()
Nicolar ()
Acido nicotinico ()
Niacor ()
Niaspan ()
Acidum nicotinicum ()
Nicotinic Acid ()
Niacin extended release ()
Wampocap ()
Nicangin ()
Nicotinate ()
Simcor ()
Niacin Td ()
P&D ID
PD001840
CAS
59-67-6
123574-58-3
101113-41-1
Tags
available
drug
Approved by
FDA
First approval
1957
Drug indication
Antihyperlipidemic
Lipid metabolism disorder
Vitamin (enzyme co-factor)
Drug Status
approved
investigational
nutraceutical
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nicotinic acid (niacin) is a form of vitamin B3 and it is the precursor for NAD and NADP. (GtoPdb)
Cell lines
1
Organisms
2
Compound Sets
30
Cayman Chemical Bioactives
37416
ChEMBL Approved Drugs
CHEMBL573
ChEMBL Drugs
CHEMBL573
Concise Guide to Pharmacology 2017/18
1588
1594
Concise Guide to Pharmacology 2019/20
1588
1594
Concise Guide to Pharmacology 2021/22
1588
1594
Concise Guide to Pharmacology 2023/24
1588
1594
Drug Repurposing Hub
DrugBank
DB00627
DrugBank Approved Drugs
DB00627
DrugCentral
2835
DrugCentral Approved Drugs
2835
DrugMAP
DMQVRZH
DrugMAP Approved Drugs
DMQVRZH
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100390
Guide to Pharmacology
1588
1594
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL573
Mcule NIBR MoA Box Subset
MCULE-3788394698
MedChem Express Bioactive Compound Library
HY-B0143
NCATS Inxight Approved Drugs
2679MF687A
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Niacin(Nicotinic-acid)
TargetMol Bioactive Compound Library
T0879
The Spectrum Collection
External IDs
67
Properties
(calculated by RDKit )
Molecular Weight
123.03
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
0.78
TPSA
50.19
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Autophagy
Metabolic Enzyme/Protease
Target
VB3
DGAT2, HCAR1, HCAR2, HCAR3, NNMT, QPRT
Endogenous Metabolite
Vitamin
Member status
member
MOA
nicotinic receptor agonist
NAD precursor, vitamin B
Indication
hypertriglyceridemia
Source data