General
Preferred name
PHLORETIN
Synonyms
RJC 02792 ()
NSC 407292 ()
Dihydronaringenin ()
Phloretin (RJC 02792) ()
NSC 407292, Dihydronaringenin ()
2',4,4',6'-Tetrahydroxydihydrochalcone ()
2',4,4',6'-Tetrahydroxy-Dihydrochalcone ()
P&D ID
PD002003
CAS
60-82-2
Tags
natural product
drug candidate
available
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Found in apple tree leaves and in the Manchurian apricot. Another naturally occuring organic molecule, phlorizin, which is found in the bark of several types of fruit tree, is converted into phloretin in the body by hydrolytic enzymes. (GtoPdb)
DESCRIPTION natural product; inhibitor of glucose uptake (Informer Set)
DESCRIPTION Blocks L-type Ca2+ channels (LOPAC library)
Cell lines
1
Organisms
2
Compound Sets
19
AdooQ Bioactive Compound Library
A10723
Cayman Chemical Bioactives
14452
Concise Guide to Pharmacology 2017/18
4285
Concise Guide to Pharmacology 2019/20
4285
Concise Guide to Pharmacology 2021/22
4285
Concise Guide to Pharmacology 2023/24
4285
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB07810
DrugMAP
DMYA50U
Guide to Pharmacology
4285
Informer Set
24173
LOPAC library
MedChem Express Bioactive Compound Library
HY-N0142
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
Phloretin(Dihydronaringenin)
TargetMol Bioactive Compound Library
T2924
The Spectrum Collection
External IDs
40
Properties
(calculated by RDKit )
Molecular Weight
274.08
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
2.32
TPSA
97.99
Fraction CSP3
0.13
Chiral centers
0.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
SLC5A1
SGLT1
SGLT2
AQP9, CLCN3, SLC23A1
Endogenous Metabolite
GLUT
SGLT
Compound status
probe
Selectivity
L-type
Pathway
GPCR/G protein
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Member status
virtual
MOA
VCAM1 Expression Inhibitors
ICAM1 Expression Inhibitors
Antioxidants
sodium/glucose cotransporter inhibitor
Source data