General
Preferred name
PHLORIZIN
Synonyms
PHLORIDZIN ()
NSC 2833 ()
Floridzin ()
Phloridzin dihydrate ()
Phlorizin dihydrate ()
Phlorizin (Phloridzin) ()
PHLORIZINE ()
Phloridzin ()
P&D ID
PD002007
CAS
60-81-1
112318-65-7
7061-54-3
Tags
available
natural product
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Found in the bark of several types of fruit tree. Within the body, phlorizin is converted into (which also occurs naturally) by hydrolytic enzymes. (GtoPdb)
Cell lines
1
Organisms
0
Compound Sets
20
AdooQ Bioactive Compound Library
A10724
Cayman Chemical Bioactives
11576
Concise Guide to Pharmacology 2017/18
4757
Concise Guide to Pharmacology 2019/20
4757
Concise Guide to Pharmacology 2021/22
4757
Concise Guide to Pharmacology 2023/24
4757
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB16771
DrugMAP
DMNARGO
EU-OPENSCREEN Bioactive Compound Library
EOS100591
Guide to Pharmacology
4757
MedChem Express Bioactive Compound Library
HY-N0143
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
Phlorizin(Phloridzin)
TargetMol Bioactive Compound Library
T2922
The Spectrum Collection
ZINC Tool Compounds
ZINC000003875408
External IDs
53
Properties
(calculated by RDKit )
Molecular Weight
436.14
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
7
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
-0.2
TPSA
177.14
Fraction CSP3
0.38
Chiral centers
5.0
Largest ring
6.0
QED
0.29
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
DNA Damage/DNA Repair
Membrane Transporter/Ion Channel
Target
Hsglt1
hSGLT2
SLC5A1, SLC5A11, SLC5A2, SLC5A3
Na+/K+ ATPase
SGLT
ATPase,SGLT
Member status
member
MOA
SGLT-1 Inhibitors
SGLT-2 Inhibitors
sodium/glucose cotransporter inhibitor
Source data