General
Preferred name
TRYPTOPHAN
Synonyms
TRYPTOPHAN (L) ()
L-tryptophan ()
Tryptophane ()
L-Tryptophane ()
(S)-Tryptophan ()
L-Tryptophane(S)-Tryptophan ()
L-Trypthophane ()
L-Tryptophan-d5 ()
Optimax Wv ()
Tryptophan, l- ()
(-)-tryptophan ()
NSC-13119 ()
Optimax ()
Pacitron ()
L-Tryptophan ()
Gppe Pdr Sach ()
Trytophan- ()
Tryptophan ((-),l,s) ()
P&D ID
PD002096
CAS
73-22-3
6912-86-3
62595-11-3
Tags
natural product
drug
endogenous
available
Approved by
FDA
Drug indication
Depression
Amino Acid
Drug Status
nutraceutical
withdrawn
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Antidepressant; precursor of serotonin (LOPAC library)
Cell lines
0
Organisms
1
Compound Sets
24
Cayman Chemical Bioactives
29600
34829
ChEMBL Approved Drugs
CHEMBL54976
ChEMBL Drugs
CHEMBL54976
Concise Guide to Pharmacology 2017/18
717
Concise Guide to Pharmacology 2019/20
717
Concise Guide to Pharmacology 2021/22
717
Concise Guide to Pharmacology 2023/24
717
Drug Repurposing Hub
DrugBank
DB00150
DrugBank Approved Drugs
DB00150
DrugCentral
2780
DrugCentral Approved Drugs
2780
DrugMAP
DMIBH7M
DrugMAP Approved Drugs
DMIBH7M
Enamine BioReference Compounds
Guide to Pharmacology
717
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL54976
MedChem Express Bioactive Compound Library
HY-N0623
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
l-tryptophan
TargetMol Bioactive Compound Library
T0439
Withdrawn 2.0
w110
External IDs
64
Properties
(calculated by RDKit )
Molecular Weight
204.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
1.12
TPSA
79.11
Fraction CSP3
0.18
Chiral centers
1.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Amino Acids and Derivatives
CASR, IDO1, SLC36A1, WARS, WARS2
Indication
anxiety, bloating, constipation, fatigue, sleeplessness
Disease Area
neurology/psychiatry, gastroenterology
MOA
serotonin receptor partial agonist
ATC
N06AX02
Toxicity type
hematological
Therapeutic Class
Antidepressants
Source data