General
Preferred name
DYPHYLLINE
Synonyms
Diprophylline ()
Diphylline ()
PMID28870136-Compound-43 ()
Dyphilline ()
Neothylline ()
Dilor-400 ()
Glyphylline ()
NSC-14305 ()
Lufyllin ()
Diprofilina ()
Dilor ()
P&D ID
PD002354
CAS
479-18-5
Tags
available
drug
Approved by
FDA
First approval
1951
Drug indication
Acute bronchial asthma
Bronchodilator
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Dyphylline is a bronchodilator and vasodilator.
(GtoPdb)
DESCRIPTION
Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects.It is used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
23
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
JUMP-Target 1 Compound Set
Ki Database
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
254.1
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
-2.21
TPSA
102.28
Fraction CSP3
0.5
Chiral centers
1.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
GPCR/G protein
Metabolic Enzyme/Protease
Target
PDE
PDE7A
Adenosine Receptor
Phosphodiesterase (PDE)
Therapeutic Class
Bronchodilator Agents
Source data
