General
Preferred name
CARBAMAZEPINE
Synonyms
NSC 169864 ()
CARBAMAZEPINE DIHYDRATE ()
CBZ ()
Carbamazepine298-46-4 ()
carbamazene ()
Carbamazepine-d10 ()
Neurotop ()
Timonil 200 Ret ()
NSC-169864 ()
Tegretol Xr ()
Carbamazepine anhydrous ()
Sirtal ()
Carnexiv ()
Neurotol ()
Finlepsin ()
GEIGY 32883 ()
Tegretal ()
Biston ()
Carbatrol ()
Tegretol Chewtab ()
Carbamazepine extended release ()
Carbagen SR ()
Tegretol-Xr ()
Stazepine ()
Epimaz Ret ()
Carbamazepinum ()
Teril Ret ()
Epimaz ()
Timonil ()
Tegretol ()
Equetro ()
Telesmin ()
G-32883 ()
Karbelex ()
Teril ()
Epitol ()
Karbamazepin ()
Timonil 400 Ret ()
Sirtal Ret ()
Tegretol Prolonged Release ()
Arbil MR ()
P&D ID
PD002445
CAS
298-46-4
132183-78-9
85756-57-6
Tags
natural product
drug
available
Approved by
FDA
First approval
1968
Drug indication
Type-1 diabetes
Analgesic
Anticonvulsant
Epilepsy
Gastric adenocarcinoma
Drug Status
investigational
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ABSORPTION
In clinical studies, carbamazepine suspension, conventional tablets, and extended-release tablets delivered equivalent amounts of drug to the systemic circulation. However, it has been observed that the suspension is somewhat faster absorbed. Furthermore, the extended-release tablet is slightly slower than the conventional tablet. The bioavailability of the extended-release tablet is 89%, compared to the suspension. Plasma levels of carbamazepine are variable. The time to peak concentration for the different formulations are as follows:; Suspension = 1.5 hours;; Conventional tablets = 4-5 hours;; Extended-release tablets = 3-12 hours.
DESCRIPTION
Carbamazepine is a tricyclic anticonvulsant.
Carbamazepine has been shown to inhibit Wnt/β-catenin signalling by binding to an allosteric site of the Wnt ligand receptor FZD8 . It does not bind to FZD5 so can be used to distinguish between these two receptors. (GtoPdb)
Carbamazepine has been shown to inhibit Wnt/β-catenin signalling by binding to an allosteric site of the Wnt ligand receptor FZD8 . It does not bind to FZD5 so can be used to distinguish between these two receptors. (GtoPdb)
DESCRIPTION
Potent and selective TRPV4 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant
(Tocriscreen Plus)
DESCRIPTION
Analgesic; anticonvulsant
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
32
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
Ki Database
LOPAC library
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Plus
VGSC-DB
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
67
Molecular Weight
236.09
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
2
cLogP
3.39
TPSA
46.33
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
7.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Pathway
Membrane Transporter/Ion Channel
Autophagy
Cell Cycle/DNA Damage
Epigenetics
Neuronal Signaling
Target
Sodium Channel
SCN10A, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN7A, SCN8A, SCN9A
Calcium Channel
HDAC
Mitophagy
Potassium Channel
Autophagy,Sodium Channel
Primary Target
Voltage-gated Sodium (NaV) Channels
MOA
Blocker
Sodium Channel Blockers
carboxamide antiepileptic
Member status
member
Indication
seizures
VGSC Target
Nav1.7
Source data
