General
Preferred name
AZATHIOPRINE
Synonyms
ML068 ()
BW 57-322 ()
1H-PURINE, 6-((1-METHYL-4-NITRO-1H-IMIDAZOL-5-YL)THIO) ()
Azathioprin ()
NSC-39084 ()
Azapress ()
Azathioprinum ()
Azasan ()
Azatioprina ()
Oprisine 50 ()
Kentaprine ()
Imuran ()
Jayempi ()
Azamune ()
Berkaprine ()
BW-57-322 ()
Immunoprin 50 ()
Azathioprine sodium salt ()
AZATHIOPRINE SODIUM ()
P&D ID
PD002465
CAS
446-86-6
Tags
available
prodrug
drug
Approved by
FDA
PMDA
First approval
1974
1968
Drug indication
Immunosuppressant
Organ transplant rejection
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Azathioprine is an immunosuppressive antimetabolite. The active drug is believed to be .
Marketed formulations may contain azathioprine sodium (PubChem CID 23678403). (GtoPdb)
DESCRIPTION Identify small-molecule modulators of Beta-Globin splicing by high throughput screening of chemical libraries. (MLP Probes)
DESCRIPTION Purine analog; inhibits DNA and RNA synthesis (Tocris Bioactive Compound Library)
DESCRIPTION Purine analog; prodrug of 6-mercaptopurine (Cat. No. 4103) (Tocriscreen Plus)
DESCRIPTION Purine analog; purine synthesis inhibitor; immunosuppressant (LOPAC library)
DESCRIPTION Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases. (BOC Sciences Bioactive Compounds)
Cell lines
3
Organisms
1
Compound Sets
29
AdooQ Bioactive Compound Library
A10107
BOC Sciences Bioactive Compounds
azathioprine-cas-446-86-6-item-84-292606
Cayman Chemical Bioactives
13987
ChEMBL Approved Drugs
CHEMBL1542
CHEMBL1200400
ChEMBL Drugs
CHEMBL1542
CHEMBL1200400
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00993
DrugBank Approved Drugs
DB00993
DrugCentral
269
DrugCentral Approved Drugs
269
DrugMAP
DMMZSXQ
DrugMAP Approved Drugs
DMMZSXQ
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
7120
JUMP-Target 1 Compound Set
2265
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0256
NCATS Inxight Approved Drugs
MRK240IY2L
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Azathioprine(Azasan)
TargetMol Bioactive Compound Library
T1237
The Spectrum Collection
Tocris Bioactive Compound Library
4099
Tocriscreen Plus
4099
External IDs
58
Properties
(calculated by RDKit )
Molecular Weight
277.04
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
1
cLogP
1.1
TPSA
115.42
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Selectivity
Purine synthesis
Pathway
Cell Cycle/Checkpoint
Endocrinology/Hormones
Apoptosis
Target
HGPRT
RAC1
HPRT1, IMPDH1, PPAT
PPAT
Rho
Primary Target
DNA, RNA and Protein Synthesis
Indication
renal homotransplantation, rheumatoid arthritis
Disease Area
transplant, rheumatology
MOA
Dehydrogenase inhibitor
Therapeutic Class
Immunosuppressive Agents
Source data