General
Preferred name
adenosine
Synonyms
D-Adenosine ()
Adenine riboside ()
Adenocard ()
Adenosine ()
SR 96225 ()
9-.beta.-d-ribofuranosyladenine ()
SR-96225 ()
Adenocor ()
Adenoscan ()
NSC-7652 ()
9-.BETA.-D-RIBOFURANOSYLADENINE ()
ADENOCOR ()
P&D ID
PD002487
CAS
58-61-7
46946-45-6
30143-02-3
142796-17-6
5536-17-4
Tags
natural product
drug
endogenous
available
Approved by
FDA
First approval
1989
Drug indication
Paroxysmal supraventricular tachycardia
Cardiac Depressant (anti-arrhythmic)
Drug Status
investigational
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Endogenous nucleoside, a component of nucleic acids and an important neurotransmitter.
(GtoPdb)
DESCRIPTION
Selective calcium-sensing receptor (CaSR) antagonist; orally active calcilytic agent
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
3
Compound Sets
28
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
Natural product-based probes and drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
49
Molecular Weight
267.1
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
4
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
-1.98
TPSA
139.54
Fraction CSP3
0.5
Chiral centers
4.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
DNA Damage/DNA Repair
Target
Nucleoside
ADORA1, ADORA2A, ADORA2B, ADORA3, PI4K2A, PI4K2B, TRPM4
Adenosine Receptor,Nucleoside Analog/Antimetabolite
Primary Target
Non-selective Adenosine
MOA
Agonist
Adenosine Receptor Agonists
Adenosine Receptor agonist
Member status
virtual
Indication
Wolff-Parkinson-White Syndrome (WPW)
Therapeutic Indication
Antiarrhythmic
Therapeutic Class
Cardiovascular
Antiarrhythmic Agents
Recommended Cell Concentration
None
Source data
