General
Preferred name
NITRENDIPINE
Synonyms
BAY-E-5009 ()
Bayotensin ()
Deiten ()
Baypress ()
Nitrendipino ()
Nidrel ()
BAY E 5009 ()
NSC-758466 ()
Nitrepin ()
nitrendipine ()
P&D ID
PD002662
CAS
39562-70-4
Tags
available
drug
First approval
1985
Drug indication
Antihypertensive
Hypertension
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION The approved drug nitrendipine is a racemic mixture of two enantiomers; (R)-nitrendipine and (S)-nitrendipine. The structure shown here does not specify stereochemistry and represents the mixture. (GtoPdb)
DESCRIPTION Ca2+ channel blocker (L-type) (Tocriscreen Plus)
DESCRIPTION Ca2+ channel blocker; antihypertensive (LOPAC library)
DESCRIPTION Non-selective P2 antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Ca2+ channel blocker (L-type) (Tocriscreen Total)
Cell lines
1
Organisms
8
Compound Sets
32
Cayman Chemical Bioactives
17549
ChEMBL Approved Drugs
CHEMBL475534
ChEMBL Drugs
CHEMBL475534
Concise Guide to Pharmacology 2017/18
2334
Concise Guide to Pharmacology 2019/20
2334
Concise Guide to Pharmacology 2021/22
2334
Concise Guide to Pharmacology 2023/24
2334
CZ-OPENSCREEN Bioactive Library
DrugBank
DB01054
DrugBank Approved Drugs
DB01054
DrugCentral
1947
DrugCentral Approved Drugs
1947
DrugMAP
DM21C09
DrugMAP Approved Drugs
DM21C09
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS101419
Guide to Pharmacology
2334
Ki Database
NITRENDIPINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL475534
Mcule NIBR MoA Box Subset
MCULE-3680092622
MedChem Express Bioactive Compound Library
HY-B0424
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Nitrendipine
TargetMol Bioactive Compound Library
T0119
The Spectrum Collection
Tocris Bioactive Compound Library
0601
Tocriscreen Plus
0601
Tocriscreen Total
External IDs
37
Properties
(calculated by RDKit )
Molecular Weight
360.13
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
1
cLogP
2.57
TPSA
107.77
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Selectivity
L-type
Pathway
Membrane Transporter/Ion Channel
Autophagy
Neuronal Signaling
Target
Calcium Channel
Autophagy,Calcium Channel
Primary Target
CaV1.x Channels (L-type)
MOA
Blocker
L-Type Calcium Channel Blockers
Member status
member
Therapeutic Class
Antihypertensive Agents
Source data