General
Preferred name
MIZORIBINE
Synonyms
HE 69 ()
NSC 289637 ()
Bredinin ()
Bredinin, NSC 289637,HE 69 ()
Mizoribina ()
NSC-289637 ()
P&D ID
PD002689
CAS
50924-49-7
50524-49-7
Tags
available
prodrug
drug
Drug indication
Transplant rejection
Drug Status
approved
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Arrests at G/S; inhibits de novo synthesis of nucleotides by inhibition of inosine monophosphate dehydrogenase
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
16
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
LOPAC library
Mcule NIBR MoA Box Subset
Natural product-based probes and drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
259.08
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
5
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
-2.7
TPSA
151.06
Fraction CSP3
0.56
Chiral centers
4.0
Largest ring
5.0
QED
0.4
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
IMP dehydrogenase
Target
HSP
monophosphate synthetase
DNA/RNA Synthesis,HCV
Pathway
Metabolic Enzyme/Protease
Cell Cycle/DNA Damage
Proteases/Proteasome
MOA
tyrosinase inhibitor
Immunosuppressive
Member status
member
Biosynthetic Origin
Nucleoside
Therapeutic Indication
Immunosuppressant
Therapeutic Class
Immunomodulatory
Antimetabolites
Source data
