General
Preferred name
KAINIC ACID
Synonyms
[3H]kainate ()
(−)-(α)-Kainic Acid hydrate ()
Digenic acid ()
Digenin ()
NSC-759587 ()
Acido kainico ()
Helminal ()
Acide kainique ()
kainate ()
(-)-(.alpha.)-Kainic Acid (hydrate) ()
P&D ID
PD002700
CAS
487-79-6
59905-23-6
4071-38-9
58002-62-3
Tags
available
drug
natural product
drug candidate
Drug indication
Discovery agent
Drug Status
approved
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Please note that the PubChem entry linked to above refers to the acid form of the compound.
(GtoPdb)
DESCRIPTION
A naturally occurring neuroexcitatory chemical that is a selective agonist for a subtype of ionotropic glutamate receptor.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Broad spectrum glutamatergic antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Excitatory amino acid receptor agonist selective for the kainate glutamate receptor subtype; conformationally restricted analog of L-glutamic acid
(LOPAC library)
DESCRIPTION
Potent excitant and neurotoxin
(Tocriscreen Total)
DESCRIPTION
Kainic acid is a naturally occurring neuroexcitatory amino acid. It is a selective agonist for a subtype of ainate-class ionotropic glutamate receptor found in seaweed. It increases production of mitochondrial dysfunction, reactive oxygen species and apoptosis in neurons in many regions of the brain. It increases glutamate release and stimulates Na channels, inducing epileptic seizures and neurocytosis (apoptosis). It has been used to study mechanisms of apoptosis and epilepsy.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
21
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugCentral
DrugCentral Approved Drugs
DrugMAP
LOPAC library
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Tocris Bioactive Compound Library
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
50
Molecular Weight
213.1
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
0
cLogP
0.33
TPSA
86.63
Fraction CSP3
0.6
Chiral centers
3.0
Largest ring
5.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Kainate
Primary Target
Kainate Receptors
MOA
Agonist
Kainate receptor agonist
Member status
member
Target
GRIA1, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5
EAAT
Pathway
Membrane Transporter/Ion Channel
Source data
