General
Preferred name
OXITRIPTAN
Synonyms
5-hydroxy-L-tryptophan ()
L-5-HTP ()
L-oxitriptan ()
L-5-Hydroxytryptophan ()
Oxyfan ()
Tryptophan, 5-hydroxy-, dl ()
Levotinine ()
Dl-oxitriptan ()
Hydroxytryptophan ()
Triptene ()
Dl-hydroxytryptophan ()
Pretonine ()
5-hydroxy-l-tryptophan ()
Levothym ()
5-hydroxytryptophan, dl- ()
Cincofarm ()
Quietim ()
Levotonine ()
Telesol ()
5-hydroxytryptophan ()
Serotonyl ()
NSC-92523 ()
5-hydroxytryptophan l-form ()
Dl-5-htp ()
DL-5-Hydroxytryptophan ()
P&D ID
PD002706
CAS
4350-09-8
Tags
natural product
drug
available
Drug indication
Discovery agent
Drug Status
investigational
approved
nutraceutical
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
The psychoactive action of 5-HTP is thought to be due to increased serotonin production in central nervous system tissue.
METABOLISM
5-Hydroxytryptophan is decarboxylated to serotonin (5-hydroxytryptamine or 5-HT) by the enzyme aromatic-L-amino-acid decarboxylase via a vitamin B6 dependent reaction in nervous tissue and in the liver.
DESCRIPTION
Serotonin precursor; antidepressant; anti-epileptic
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
22
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
Enamine BioReference Compounds
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
46
Molecular Weight
220.08
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
4
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
0.83
TPSA
99.34
Fraction CSP3
0.18
Chiral centers
1.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Amino Acids and Derivatives
SLC36A1, SLC36A2
Endogenous Metabolite
Indication
insomnia
MOA
neurotransmitter
Pathway
Metabolic Enzyme/Protease
Source data
