General
Preferred name
HYDROCORTISONE
Synonyms
cortisol ()
Hydrocortisone base ()
Hydrocortisone(Cortisol) ()
Hydrocortisone (NSC 10483) ()
Hi-Cor ()
Germoloids HC ()
Hydrocort In Cetomacrogol For A ()
Neo-Cortef ()
Perinal ()
Otosporin ()
Flexicort ()
Ophthocort ()
Penecort ()
Canesten HC ()
Terra-Cortril ()
Efcortelan P ()
Plenadren ()
Hydrocort In Calamine Oily ()
Otoseptil ()
Derma Care Hydrocort ()
Cor-Oticin ()
Anusol Soothing Relief ()
Eurax-Hc ()
Aeroseb-Hc ()
Quinocort ()
Colocort ()
Epicort ()
Timocort ()
Glycort ()
Stie-Cort ()
Daktacort Hydrocort ()
Dermacort ()
Hc #1 ()
Cortifoam ()
Nystaform-HC ()
Acticort ()
Anusol Plus HC ()
Anusol hc ()
Mildison Lipocream ()
Terra-Cortril Nystatin ()
Balneol-Hc ()
Ala-Cort ()
Locoid ()
Cortef ()
Nogenic hc ()
Proctocream HC ()
Jungle For ()
Dome-Cort ()
Hc #4 ()
Evacort ()
Anflam ()
Dermaspray Demang ()
Hydroderm HC ()
Gregoderm ()
Xyloproct ()
Ala-Scalp ()
Zenoxone ()
Anusol-Hc ()
Eldecort ()
Calmurid HC ()
Tri-Cicatrin ()
Medicort ()
Topisone ()
Nutracort ()
Alkindi sprinkle ()
Uniroid Hc ()
Proctocort ()
Micort-Hc ()
Texacort ()
Hydroderm ()
Cetacort ()
Anucort-Hc ()
Acetasol HC ()
Hidrocortisona ()
H-Cort ()
Cortenema ()
Hytone ()
Anugesic HC ()
Proctofoam HC ()
Beta-Hc ()
Cortril ()
Cipro HC ()
Timodine ()
Daktacort ()
Hydrocortone ()
Dioderm ()
Hc (hydrocortisone) ()
Hydrocort In Wte Soft Paraf ()
Hydro-Rx ()
Sential HC ()
Proctosedyl ()
Cort-Dome ()
Corlan ()
NSC-10483 ()
Cobadex ()
Exe-Cort ()
Alphaderm ()
U-Cort ()
Hydrocortisone In Absorbase ()
Uniroid ()
Econacort ()
Cortenem ()
Nybadex ()
Eurax-Hydrocort ()
Synacort ()
Hydrocortisone-d4 ()
P&D ID
PD002713
CAS
50-23-7
73565-87-4
Tags
available
drug
Approved by
FDA
EMA
First approval
1952
Drug indication
Glucocorticoid
Inflammation
Congenital adrenal hyperplasia
Drug Status
approved
vet_approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cortisol is an endogenous adrenal glucocorticoid with immunosuppressant action. Approved as hydrocortisone. Hydrocortisone is a glucocorticoid receptor agonist.
Marketed formulations may contain hydrocortisone acetate (PubChem CID 5744). (GtoPdb)
DESCRIPTION Adrenal glucocorticoid; immunosuppressant (Tocriscreen Plus)
DESCRIPTION Primary glucocorticoid secreted by the adrenal cortex (LOPAC library)
DESCRIPTION Non-steroidal androgen receptor antagonist (Tocris Bioactive Compound Library)
Cell lines
1
Organisms
2
Compound Sets
31
AdooQ Bioactive Compound Library
A10457
Cayman Chemical Bioactives
20739
26500
ChEMBL Approved Drugs
CHEMBL389621
ChEMBL Drugs
CHEMBL389621
Concise Guide to Pharmacology 2017/18
2868
Concise Guide to Pharmacology 2019/20
2868
Concise Guide to Pharmacology 2021/22
2868
Concise Guide to Pharmacology 2023/24
2868
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00741
DrugBank Approved Drugs
DB00741
DrugCentral
1388
DrugCentral Approved Drugs
1388
DrugMAP
DMGEMB7
DrugMAP Approved Drugs
DMGEMB7
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101695
Guide to Pharmacology
2868
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL389621
MedChem Express Bioactive Compound Library
HY-N0583
NCATS Inxight Approved Drugs
WI4X0X7BPJ
NIH Clinical Collections (NCC)
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2FWQEMKA13C7
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Hydrocortisone
TargetMol Bioactive Compound Library
T1614
Tocris Bioactive Compound Library
4093
Tocriscreen Plus
4093
External IDs
100
Properties
(calculated by RDKit )
Molecular Weight
362.21
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
1.78
TPSA
94.83
Fraction CSP3
0.81
Chiral centers
7.0
Largest ring
6.0
QED
0.7
Structural alerts
2
aggregator (ZINC)
Aggregators
aggregator (Aggregator Advisor)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Selectivity
Cortisol
Pathway
Metabolism
Immunology/Inflammation
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Target
Glucocorticoid Receptor
ANXA1, NOS2, NR3C1, NR3C2
Endogenous Metabolite
Primary Target
Glucocorticoid Receptors
Disease Area
dermatology, neurology/psychiatry
Indication
eczema, psoriasis, seborrheic dermatitis, itching
MOA
Glucocorticoid Receptor agonist
Therapeutic Class
Antiinflammatory Agents
Source data