General
Preferred name
quinidine
Synonyms
QUINIDINE GLUCONATE ()
Quinidine hydrochloride monohydrate ()
Quinidine hydrochloride ()
Chinidin Sodium, Pitayine Sodium, β-quinine Sodium, (+)-quinidine Sodium ()
Chinidin Sodium, Pitayine Sodium, ??quinine Sodium, (+)-quinidine Sodium ()
Quinidine (15% dihydroquinidine) ()
Quinidine hemisulfate hydrate ()
Quinidine sulfate dihydrate ()
Conquinine ()
Chinidin Sodium, Pitayine Sodium, ¦Â-quinine Sodium, (+)-quinidine Sodium ()
Quinidine-d3 ()
Quinact ()
NSC-757297 ()
Gluquinate ()
Dura-tab ()
Quinidine mono-d-gluconate ()
Gluconic acid quinidine salt ()
Duraquin ()
Quinidine monogluconate, d- ()
Quinalan ()
Quinaglute ()
Quinatime ()
.beta.-quinidine ()
Kinidin ()
(8r,9s)-quinidine ()
Pitayine ()
NSC-10004 ()
Quinidex ()
Quinidine sulphate ()
Quinidex extentabs ()
AVP-786 COMPONENT QUINIDINE SULFATE ()
Cin-Quin ()
Quinicardine ()
Quinidine sulphate dihydrate ()
Quinidine sulfate anhydrous ()
Quinidini sulfas ()
QUINIDINE SULFATE COMPONENT OF AVP-786 ()
Quinidine sulfate hydrate ()
Quinora ()
Quinidine, sulfate (2:1) (salt) ()
Quinidine sulphate anhydrous ()
Quinidine sulfate ()
P&D ID
PD002895
CAS
7054-25-3
6151-40-2
6591-63-5
101143-86-6
56-54-2
1267657-68-0
Tags
natural product
drug
probe
available
Approved by
FDA
First approval
1962
1950
Drug Status
investigational
approved
Max Phase
4.0
Drug indication
Cardiac Depressant (anti-arrhythmic)
Probe info
Probe type
calculated probe
Probe sources
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Quinidine is a stereoisomer of . It acts as a class I antiarrhythmic agent, blocking the fast inward sodium current (INa).
DESCRIPTION Quinidine is a stereoisomer of . It acts as a class I antiarrhythmic agent, blocking the fast inward sodium current (INa).

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
DESCRIPTION Conquinine is a Cytochrome P450 2D6 inhibitor. It is a dextrorotatory stereoisomer of quinine extracted from the bark of the Cinchona tree and similar plant species. It is an alkaloid with class 1A antiarrhythmic and antimalarial effects. It also blocks muscarinic and alpha-adrenergic neurotransmission. It stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thus inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential. It acts primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. (BOC Sciences Bioactive Compounds)
DESCRIPTION Quinidine is a voltage-gated sodium channel blocker, exhibiting antimuscarinic and antimalarial properties. (BOC Sciences Bioactive Compounds)
Cell lines
2
Organisms
4
Compound Sets
28
BOC Sciences Bioactive Compounds
conquinine-cas-56-54-2-293458
quinidine-sulfate-dihydrate-cas-6591-63-5-377520
Cayman Chemical Bioactives
20356
28884
ChEMBL Approved Drugs
CHEMBL1200437
CHEMBL1294
CHEMBL3707183
ChEMBL Drugs
CHEMBL1200437
CHEMBL1294
CHEMBL3707183
Concise Guide to Pharmacology 2017/18
2342
Concise Guide to Pharmacology 2019/20
2342
Concise Guide to Pharmacology 2021/22
2342
Concise Guide to Pharmacology 2023/24
2342
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00908
DrugBank Approved Drugs
DB00908
DrugCentral
2346
DrugCentral Approved Drugs
2346
Enamine BioReference Compounds
Guide to Pharmacology
2342
JUMP-Target 1 Compound Set
441074
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1294
MedChem Express Bioactive Compound Library
HY-B1302
HY-B1751
NCATS Inxight Approved Drugs
ITX08688JL
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
Probe Miner (suitable probes)
P10635/1490042
Selleckchem Bioactive Compound Library
quinidine-hydrochloride-monohydrate
quinidine-sulfate
TargetMol Bioactive Compound Library
T0266
The Spectrum Collection
External IDs
90
Properties
(calculated by RDKit )
Molecular Weight
324.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
2
cLogP
3.17
TPSA
45.59
Fraction CSP3
0.45
Chiral centers
5.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Anti-infection
Apoptosis
Metabolic Enzyme/Protease
Target
Potassium Channel
Sodium Channel
KCNA5, KCNA7, KCNH1, KCNH2, KCNH5, KCNK1, KCNK6, SCN5A, SLC29A4
KCNK1
Parasite
Cytochrome P450
Member status
member
MOA
P-Glycoprotein (MDR-1) Inhibitors
Sodium Channel inhibitor
Sodium Channel blocker
Indication
malaria, atrial fibrillation (AF), ventricular arrhythmias
Disease Area
infectious disease, cardiology
Solubility
0.05 g/100 mL
Source data