General
Preferred name
prednisolone
Synonyms
Metacortandralone ()
Hydroretrocortine ()
Predonine ()
Prednisolone (NSC-9900) ()
NSC-9900 ()
Precortisyl ()
Neo-Delta-Cortef ()
NSC-9120 ()
Deltacortril ()
Equisolon ()
Verdeso ()
Tridesilon ()
Scheriproct ()
Servisone ()
Dilacort ()
Delta-cortef ()
Dekotil ()
Fernisolone-p ()
Meti-derm ()
Poly-Pred ()
Sterane ()
Cortalone ()
Meticortelone ()
Pred-G ()
Hydeltra-Tba ()
Deltalone ()
Pevanti ()
Desowen ()
Prelone ()
Hydeltra ()
Precortisyl fte ()
P&D ID
PD002902
CAS
50-24-8
Tags
natural product
drug
probe
available
Approved by
FDA
First approval
1955
Drug indication
Glucocorticoid
Multiple sclerosis
Solid tumour/cancer
Drug Status
vet_approved
approved
Max Phase
4.0
Probe info
Probe type
experimental probe
Probe sources
Chemical Probes.org
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Prednisolone is a synthetic glucocorticoid. Marketed formulations may contain prednisolone sodium phosphate, prednisolone acetate, prednisolone hexanoate or prednisolone. (GtoPdb)
MOA Glucocorticoid competitive, Agonist (Chemical Probes.org)
Cell lines
11
Organisms
1
Compound Sets
26
Cayman Chemical Bioactives
20866
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL131
ChEMBL Drugs
CHEMBL131
Chemical Probes.org
prednisolone
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00860
DrugBank Approved Drugs
DB00860
DrugCentral
2245
DrugCentral Approved Drugs
2245
DrugMAP
DMQ8FR2
DrugMAP Approved Drugs
DMQ8FR2
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101333
Guide to Pharmacology
2866
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL131
MedChem Express Bioactive Compound Library
HY-17463
NCATS Inxight Approved Drugs
9PHQ9Y1OLM
NIH Clinical Collections (NCC)
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2FW5MHAZ4ZDP
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Prednisolone(Hydroretrocortine)
TargetMol Bioactive Compound Library
T1560
External IDs
55
Properties
(calculated by RDKit )
Molecular Weight
360.19
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
1.56
TPSA
94.83
Fraction CSP3
0.71
Chiral centers
7.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Glucocorticoid Receptor agonist
Target
Glucocorticoid Receptor
NR3C1, NR3C2, SERPINA6
Endogenous Metabolite
Glucocorticoid Receptor,Immunology & Inflammation related
NR3C1
Pathway
Metabolism
Immunology/Inflammation
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Disease Area
ophthalmology, dermatology, infectious disease
Indication
conjunctivitis, rosacea, punctate keratitis, shingles, iritis, cyclitis
Therapeutic Class
Anticancer Agents
Target class
Nuclear Receptor
Target subclass
Nuclear Hormone Receptor
Source data