General
Preferred name
DOXAZOSIN
Synonyms
DOXAZOSIN MESYLATE ()
UK 33274 mesylate ()
Doxazosin (mesylate) ()
UK 33274 ()
Doxazosin-d8 (hydrochloride) ()
UK-33,274-27 ()
Larbex XL ()
Slocinx XL ()
Colixil XL ()
Raporsin XL ()
UK-33274-27 ()
Doxazosin (as mesilate) ()
Doxadura ()
Doxzogen XL ()
Cardura ()
NSC-759284 ()
Alfadil ()
Doxazosin Mesilate ()
Cascor ()
Doxazosin methanesulfonate ()
Oxandosin XL ()
Cardura Xl ()
Cardozin XL ()
C02CA04 ()
UK-33274 ()
P&D ID
PD003016
CAS
77883-43-3
74191-85-8
137888-77-8
1219803-95-8
Tags
natural product
drug
available
Approved by
FDA
First approval
1990
Drug indication
Antihypertensive
Hypertension
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Doxazosin blocks α1-adrenoceptors.
Marketed formulations may contain doxazosin mesylate (PubChem CID 62978). (GtoPdb)
DESCRIPTION High affinity and selective 5-HT2B antagonist (Tocris Bioactive Compound Library)
DESCRIPTION alpha1 antagonist (Tocriscreen Plus)
DESCRIPTION alpha1 adrenoceptor blocker (LOPAC library)
DESCRIPTION Doxazosin mesylate is an α1-selective alpha blocker used to treat high blood pressure and urinary retention associated with benign prostatic hyperplasia. (BOC Sciences Bioactive Compounds)
Cell lines
4
Organisms
4
Compound Sets
33
AdooQ Bioactive Compound Library
A10334
BOC Sciences Bioactive Compounds
doxazosin-mesylate-cas-77883-43-3-item-84-98452
Cayman Chemical Bioactives
18633
30979
ChEMBL Approved Drugs
CHEMBL1200561
CHEMBL707
ChEMBL Drugs
CHEMBL1200561
CHEMBL707
Concise Guide to Pharmacology 2017/18
7170
Concise Guide to Pharmacology 2019/20
7170
Concise Guide to Pharmacology 2021/22
7170
Concise Guide to Pharmacology 2023/24
7170
DrugBank
DB00590
DrugBank Approved Drugs
DB00590
DrugCentral
954
DrugCentral Approved Drugs
954
DrugMAP
DM9PLRH
DrugMAP Approved Drugs
DM9PLRH
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101317
Guide to Pharmacology
7170
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL707
MedChem Express Bioactive Compound Library
HY-B0098A
NCATS Inxight Approved Drugs
NW1291F1W8
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Doxazosin-mesylate
doxazosin
TargetMol Bioactive Compound Library
T0101
The Spectrum Collection
Tocris Bioactive Compound Library
2964
Tocriscreen Plus
2964
External IDs
61
Properties
(calculated by RDKit )
Molecular Weight
451.19
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
3
cLogP
1.72
TPSA
112.27
Fraction CSP3
0.35
Chiral centers
1.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
alpha1
Pathway
GPCR/G protein
Neuronal Signaling
Autophagy
Target
??1-adrenergic receptor
Adrenergic Receptor
Mitophagy
Primary Target
Adrenergic ?1 Receptors
MOA
Antagonist
alpha1-Adrenoceptor Antagonists
Apoptosis Inducers
Member status
virtual
Therapeutic Class
Antihypertensive Agents
Source data