General
Preferred name
dexamethasone
Synonyms
Prednisolone F ()
Hexadecadrol ()
MK 125 ()
NSC 34521 ()
[3H]dexamethasone ()
Dexamethasone50-02-2 ()
Dexamethasone (MK-125) ()
NSC 34521, Hexadecadrol, Prednisolone F,MK-125 ()
Dexamethasone-d4 ()
Dextenza ()
ISV-305 ()
Neodecadron ()
Fluormethylprednisolone ()
Mymethasone ()
Decadron-La ()
Decadron ()
Oradexon ()
Gppe Ear Spy ()
Ozurdex ()
Sofradex ()
Dexacortisyl ()
Spersadex Comp ()
Dropodex ()
Dexone 4 ()
Martapan ()
dexamethasone valerate ()
Dexafree ()
Otomize ()
Decaderm ()
Tobradex ()
Kortico Injection ()
Decadron-75 ()
NSC-34521 ()
Hemady ()
dexamethasone palmitate ()
Aeroseb-Dex ()
Dalalone ()
Dexacen-4 ()
Dexone ()
Dexone 1.5 ()
Dexair ()
Dexamethasone Metasulfobenzoate Sodium ()
Dexycu ()
Dexycu kit ()
Decaspray ()
OTO-104 ()
Dexsol ()
Hexadrol ()
Dexamethasone Intensol ()
Maxitrol ()
Maxidex ()
Dexone 0.75 ()
Dexone 0.5 ()
Dexacort ()
Dexamethasone ()
AEROSEB-DEX ()
DECADERM ()
DECADRON-75 ()
DECASPRAY ()
DEXACORTISYL ()
DEXAFREE ()
DEXAMETHASONE INTENSOL ()
DEXAMETHASONE METASULFOBENZOATE SODIUM ()
DEXONE 0.5 ()
DEXONE 0.75 ()
DEXONE 1.5 ()
DEXONE 4 ()
DEXSOL ()
DEXTENZA ()
DEXYCU ()
DEXYCU KIT ()
DROPODEX ()
Decadron-LA ()
FLUORMETHYLPREDNISOLONE ()
GPPE EAR SPY ()
HEMADY ()
HEXADROL ()
MARTAPAN ()
MAXIDEX ()
MAXITROL ()
ORADEXON ()
OTOMIZE ()
SOFRADEX ()
SPERSADEX COMP ()
TOBRADEX ()
P&D ID
PD003027
CAS
50-02-2
137098-19-2
23495-06-9
1050677-47-8
2483831-63-4
Tags
drug
available
Approved by
PMDA
FDA
EMA
First approval
1958
Drug indication
Glucocorticoid
Rheumatoid arthritis
Drug Status
investigational
vet_approved
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCPRITION
An anti-inflammatory 9-fluoro-glucocorticoid.
INDICATION
Injection: for the treatment of endocrine disorders, rheumatic disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.;
Ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.;
Ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus;
Topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses;
Oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy;
Intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps
Ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.;
Ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus;
Topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses;
Oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy;
Intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
18
Organisms
2
Compound Sets
32
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
JUMP-Target 1 Compound Set
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
NURSA ligand set
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
172
Molecular Weight
392.2
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
1.9
TPSA
94.83
Fraction CSP3
0.73
Chiral centers
8.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
GPCR/G protein
Immunology/Inflammation
Metabolism
Antibody-drug Conjugate/ADC Related
Anti-infection
Autophagy
Vitamin D Related/Nuclear Receptor
Target
Glucocorticoid Receptor
IL Receptor
ANXA1, NOS2, NR0B1, NR3C1, NR3C2
Glucocorticoid agonist
ANXA1
ADC Cytotoxin
antibiotic
Bacterial
Complement System
Mitophagy
SARS-CoV
Autophagy,Complement System,COVID-19,Glucocorticoid Receptor,IL Receptor,Mitophagy
MOA
GR agonist
Antiinflammatory Drugs
Glucocorticoid Receptor agonist
Member status
member
Disease Area
endocrinology, rheumatology, allergy, gastroenterology, hematology, neurology/psychiatry, dermatology
Indication
hypercalcemia, rheumatoid arthritis, psoriatic arthritis, osteoarthritis, allergic rhinitis, ulcerative colitis, anemia, multiple sclerosis, enteritis, lupus, dermatitis herpetiformis (DH), nephrotic syndrome, psoriasis
Therapeutic Class
Antiinflammatory Agents
Recommended Cell Concentration
None
Source data
