General
Preferred name
HYDROCORTISONE ACETATE
Synonyms
Hydrocortisone 21-acetate ()
Cortisol 21-acetate ()
Cortisol acetate ()
Barquinol HC ()
Cortril ()
Genticin HC ()
Gppe Ear Susp ()
Hepacort Plus ()
Gppe Foam Aero ()
Hydrocortone ()
NSC-741 ()
Hc45 Hydrocort ()
Hydrocortisoni acetas ()
Dricort ()
Gppe Eye Crm ()
Chloromycetin Hydrocort ()
Framycort ()
Fucidin H ()
Hydrocal ()
Hemsol-Hc ()
Neo-Cortef ()
Micort-Hc ()
Cortucid ()
Cortifoam ()
Gentisone HC ()
Orabase Hca ()
Colifoam ()
Lanacort ()
Cortef Acetate ()
Epifoam ()
P&D ID
PD003041
CAS
50-03-3
42016-02-4
Tags
natural product
drug
available
Approved by
FDA
First approval
1951
Drug Status
vet_approved
approved
Max Phase
4.0
Drug indication
Glucocorticoid
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Hydrocortisone acetate, a derivative of hydrocortisone, is a corticosteroid compound that has a broad range of anti-inflammatory and immunosuppressive effects and thus widely used in therapy of skin wound. (BOC Sciences Bioactive Compounds)
Compound Sets
18
BOC Sciences Bioactive Compounds
hydrocortisone-acetate-cas-50-03-3-322029
Cayman Chemical Bioactives
29390
ChEMBL Approved Drugs
CHEMBL1091
ChEMBL Drugs
CHEMBL1091
Drug Repurposing Hub
DrugBank
DB14539
DrugBank Approved Drugs
DB14539
DrugCentral
4213
DrugCentral Approved Drugs
4213
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100563
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1091
MedChem Express Bioactive Compound Library
HY-B1183
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
hydrocortisone-acetate
TargetMol Bioactive Compound Library
T1243
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
404.22
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
0
cLogP
2.35
TPSA
100.9
Fraction CSP3
0.78
Chiral centers
7.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Metabolism
Immunology/Inflammation
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Target
Annexin A1
Glucocorticoid Receptor
NR3C1
Endogenous Metabolite
Immunology & Inflammation related
Indication
corticosteroid-responsive dermatoses
MOA
Glucocorticoid Receptor agonist
Solubility
Soluble in DMSO (38 mg/mL)
Source data