General
Preferred name
cephalexin
Synonyms
cefalexin ()
Cephacillin ()
Cephalexin monohydrate ()
CEPHALEXIN ANHYDROUS ()
CEPHALEXIN HYDRATE ()
Cefalexin hydrochloride ()
Cephacillin hydrochloride ()
Cefalexin hydrate ()
Cephacillin hydrate ()
Cephalexin (hydrochloride) ()
Cephalexin (monohydrate) ()
CEPHALEXIN HYDROCHLORIDE ()
Anhydrous cephalexin ()
Efalexin ()
Taicelexin ()
Uphalexin ()
Lilly-66873 ()
Keflex ()
Cefalexin anhydrous ()
Oracocin ()
Keftab ()
Felexin ()
Keflet ()
Durantel ()
NSC-758162 ()
Cefaleksin ()
S-6437 ()
Sinthecillin ()
Alsporin ()
Iwalexin ()
Cefadros ()
Cefalexina ()
Garasin ()
Kefloridina ()
Pyassan ()
Cefalexine ()
Mamalexin ()
Carnosporin ()
Cephamasten ()
66873 ()
Tenkorex ()
LY-66873 ()
Cefalexin monohydrate ()
Panixine Disperdose ()
Novolexin ()
Cefanex ()
Biocef ()
Ceporex ()
Kiflone ()
Cephalexin ()
LY-061188 ()
Cephalexin hcl ()
LY061188 ()
P&D ID
PD003054
CAS
15686-71-2
14101-75-8
23325-78-2
105879-42-3
59695-59-9
Tags
available
drug
covalent binder
Approved by
FDA
First approval
1987
1971
Drug indication
Antibacterial
Bacterial infection
Drug Status
approved
vet_approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ROE Cephalexin is over 90% excreted in the urine after 6 hours[A179026] by glomerular filtration and tubular secretion[Label,L6550,L6553] with a mean urinary recovery of 99.3%.[A179032] Cephalexin is unchanged in the urine.[A179026,A179029,A179032]
PHARMACODYNAMICS Cephalexin (also called Cefalexin) is a first generation cephalosporin antibiotic.[A179071,A179074] It is one of the most widely prescribed antibiotics, often used for the treatment of superficial infections that result as complications of minor wounds or lacerations.[Label] It is effective against most gram-positive bacteria through its inihibition of the cross linking reaction between N-acetyl muramicacid and N-acetylglucosamine in the cell wall, leading to cell lysis.[A179083]
INDICATION Cephalexin is indicated for the treatment of certain infections caused by susceptible bacteria.[Label,L6550,L6553] These infections include respiratory tract infections, otitis media, skin and skin structure infections, bone infections, and genitourinary tract infections.[Label,L6550,L6553]
MOA Cephalexin is a first generation cephalosporin antibiotic.[A179071,A179074] Cephalosporins contain a beta lactam and dihydrothiazide.[A179071] Unlike penicillins, cephalosprins are more resistant to the action of beta lactamase.[A179071] Cephalexin inhibits bacterial cell wall synthesis, leading breakdown and eventualy cell death.[Label]
HALF-LIFE The half life of cephalexin is 49.5 minutes in a fasted state and 76.5 minutes with food though these times were not significantly different in the study.[A179032]
TOXICITY Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting.[Label] An overdose is generally managed through supportive treatment as diuresis, dialysis, hemodialysis, and charcoal hemoperfusion are not well studied in this case.[Label]; ; The oral median lethal dose of cephalexin in rats is >5000 mg/kg. The oral LD50 in a monkey is >1g/kg and the lowest dose causing a toxic effect in humans is 14mg/kg.[MSDS]; ; Cephalexin has not been shown to be harmful in pregnancy and is not associated with teratogeniticy.[Label] Cephalexin is present in breast milk, though infants may be exposed to <1% of the dose given to the mother.[Label] The effects of breast milk exposure to cephalexin have not been established and so caution must be exercised and the risk and benefit of cephalexin use in breastfeeding must be weighed.[Label]; ; Cephalexin has not been studied for carcinogenicity or mutagenicity.[Label] Cephalexin has no affect on fertility in rats.[Label]
ABSORPTION Well absorbed from the upper gastrointestinal tract with nearly 100% oral bioavailability.[A179032,A179035] Cephalexin is not absorbed in the stomach but is absorbed in the upper intestine.[A179065]; ; Patients taking 250mg of cephalexin reach a maximum plasma concentration of 7.7mcg/mL and patients taking 500mg reach 12.3mcg/mL.[A179026]
METABOLISM Cephalexin is not metabolized in the body.[A179029,Label,L6550,L6553]
DESCRIPTION Cephalexin is a cephalosporin antibacterial. (GtoPdb)
DESCRIPTION Cefalexin hydrochloride is a cephalosporin antibiotic. It is a first-generation cephalosporin antibiotic introduced in 1967 by Eli Lilly and Company. It is an orally administered agent with a similar antimicrobial spectrum to the intravenous agents cefalotin and cefazolin. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
2
Compound Sets
27
BOC Sciences Bioactive Compounds
cephalexin-hydrochloride-cas-59695-59-9-item-84-463293
Cayman Chemical Bioactives
9002009
ChEMBL Approved Drugs
CHEMBL1727
CHEMBL1200544
CHEMBL1200366
ChEMBL Drugs
CHEMBL1727
CHEMBL1200544
CHEMBL1200366
Concise Guide to Pharmacology 2017/18
4832
Concise Guide to Pharmacology 2019/20
4832
Concise Guide to Pharmacology 2021/22
4832
Concise Guide to Pharmacology 2023/24
4832
CovBinderInPDB
CBR006245
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00567
DrugBank Approved Drugs
DB00567
DrugCentral
571
DrugCentral Approved Drugs
571
DrugMAP
DMD5JU8
DrugMAP Approved Drugs
DMD5JU8
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100358
Guide to Pharmacology
4832
MedChem Express Bioactive Compound Library
HY-B0200
HY-B0200B
HY-B0200A
NCATS Inxight Approved Drugs
5SFF1W6677
NIH Clinical Collections (NCC)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
Cephalexin-(Cefalexin)
TargetMol Bioactive Compound Library
T1008
External IDs
91
Properties
(calculated by RDKit )
Molecular Weight
347.09
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
1
cLogP
0.44
TPSA
112.73
Fraction CSP3
0.31
Chiral centers
3.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Anti-infection
Target
PBPs
antibiotic
Bacterial
Penicillin-binding protein (PBP)
Antibiotics,Bacterial
MOA
Antibacterial
bacterial cell wall synthesis inhibitor
Disease Area
infectious disease, otolaryngology
Indication
respiratory tract infections, otitis, skin infections, bone and joint infections, genitourinary tract infections
Therapeutic Class
Antibiotics
Source data