General
Preferred name
NITRAZEPAM
Synonyms
Nitrazepam-d5 ()
Nitrazepam-d5 (exempt preparation) ()
Ro-53059 ()
RO-5-3059 ()
Benzalin ()
RO 5-3059 ()
Nitrados ()
Unisomnia ()
Mogadon ()
Somnite ()
N05CD02 ()
NSC-58775 ()
Nitrazepamum ()
Ro-45360 ()
Remnos ()
RO 4-5360 ()
RO-4-5360 ()
P&D ID
PD003070
CAS
146-22-5
136765-45-2
Tags
natural product
drug
available
Drug indication
Epilepsy
Anticonvulsant
Sedative-Hypnotic
Insomnia
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
TOXICITY
An overdose of nitrazepam may lead to impaired breathing, dizziness, decreased cognition and balance, bluish nails and lips, slurred speech, and extreme somnolence, among others. In severe overdose, these symptoms may progress to a coma with a possibility of death.
MOA
Nitrazepam belongs to a group of medicines called benzodiazepines. This drug affects central benzodiazepine receptors, which are associated with inhibitory GABA (gamma amino butyric acid)receptors, leading to enhanced GABA binding activity. GABA is a major neurotransmitter in the brain, which causes somnolence, relaxation of muscles, a decrease in anxiety and general central nervous system depression. Nitrazepam has anticonvulsant properties that may be attributed to its ability to bind to voltage-dependent sodium channels. Sustained repetitive firing seems to be limited by benzodiazepines effect of slowing recovery of sodium channels from inactivation.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Ki Database
NIH Clinical Collections (NCC)
NPC Screening Collection
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
281.08
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
2.38
TPSA
84.6
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
7.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Antianxiety Agents
Source data
