General
Preferred name
MEROPENEM
Synonyms
SM 7338 ()
Meropenem Trihydrate ()
MEROPENEM ANHYDROUS ()
SM 7338 trihydrate ()
Meropenem (trihydrate) ()
(4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid trihydrate ()
ICI 194,660 ()
SM-7338 ()
Merrem i.v. ()
Merrem ()
Meropenem trihydrate ()
Meropenem hydrate ()
NSC-759621 ()
Meropenem (as trihydrate) ()
ICI-194660 ()
Merrem iv ()
Meropenem, anhydrous ()
Meronem ()
Meropenem (hydrate) ()
Meropenem-d6 ()
P&D ID
PD003103
CAS
96036-03-2
119478-56-7
1133424-00-6
Tags
available
drug
covalent binder
Approved by
FDA
First approval
1996
Drug indication
Antibacterial
Bacterial infection
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Meropenem is a parenterally delivered, broad-spectrum carbapenem antibacterial. It is active against Gram-positive and Gram-negative bacteria, and is effective against aerobic and anaerobic pathogens including Klebsiella, E. coli, Enterococcus, Clostridium spp. (GtoPdb)
Cell lines
0
Organisms
5
Compound Sets
23
AdooQ Bioactive Compound Library
A17438
A10569
Cayman Chemical Bioactives
16068
28616
ChEMBL Approved Drugs
CHEMBL127
ChEMBL Drugs
CHEMBL127
CovBinderInPDB
CBR000274
CBR000275
CBR000858
CBR000860
CBR000861
CBR000862
CBR000881
CBR000886
CBR000887
CBR001354
CBR001355
CBR001356
CBR001357
CBR001494
CBR001734
CBR001735
CBR002179
CBR002180
CBR002607
CBR003136
CBR003558
CBR004083
CBR006169
CBR006594
CBR006820
CBR006821
Drug Repurposing Hub
DrugBank
DB00760
DrugBank Approved Drugs
DB00760
DrugCentral
1709
DrugCentral Approved Drugs
1709
DrugMAP
DM62UHC
DrugMAP Approved Drugs
DM62UHC
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100723
Guide to Pharmacology
10829
MedChem Express Bioactive Compound Library
HY-13678A
HY-13678
NCATS Inxight Approved Drugs
YOP6PX0BAO
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
meropenem-trihydrate
TargetMol Bioactive Compound Library
T0224
External IDs
68
Properties
(calculated by RDKit )
Molecular Weight
383.15
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
0
cLogP
-0.31
TPSA
110.18
Fraction CSP3
0.71
Chiral centers
6.0
Largest ring
5.0
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Anti-infection
Target
??-Lactamase
D-alanyl-D-alanine carboxypeptidase DacB
¦Â-Lactamase
antibiotic
Bacterial
Penicillin-binding protein (PBP)
MOA
Antibiotic agonist
bacterial cell wall synthesis inhibitor
Indication
skin infections, intra-abdominal infections, meningitis
Therapeutic Class
Antibiotics
Source data