General
Preferred name
TIVANTINIB
Synonyms
ARQ-197 ()
ARQ197 ()
ARQ 197 ()
(3R,4R)-ARQ 198 ()
(rel)-ARQ 197 ()
(rel)-(3R,4R)-ARQ 198 ()
Tivantinib (ARQ 197) ()
(rel)-Tivantinib ()
P&D ID
PD003457
CAS
905854-02-6
1000873-98-2
905853-99-8
Tags
available
drug candidate
Drug indication
Hepatocellular carcinoma
Solid tumour/cancer
Drug Status
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tivantinib is an allosteric inhibitor of c-MET kinase (hepatocyte growth factor receptor), with antineoplastic potential .
(GtoPdb)
DESCRIPTION
inhibitor of MET; inhibitor of microtubule assembly
(Informer Set)
DESCRIPTION
Tivantinib (ARQ-197) is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. c-Met inhibitor ARQ 197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing consitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis. Check for active clinical trials or closed clinical trials using this agent
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
4
Organisms
0
Compound Sets
18
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Clinical kinase drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
Guide to Pharmacology
Informer Set
LINCS compound set
PKIDB
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
369.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
6
Aromatic Ring Count
4
cLogP
3.59
TPSA
66.89
Fraction CSP3
0.22
Chiral centers
2.0
Largest ring
6.0
QED
0.53
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
MET
c-Met
c-MET inhibitor
c-Met/HGFR
Apoptosis related,c-Met
Compound status
clinical
Pathway
Tyrosine Kinase/Adaptors
Apoptosis
Protein Tyrosine Kinase/RTK
MOA
tyrosine kinase inhibitor
Source data
