General
Preferred name
PIK-93
Synonyms
PIK 93 ()
PIK93 ()
N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide ()
P&D ID
PD003469
CAS
593960-11-3
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION inhibitor of PI3K catalytic subunit gamma (Informer Set)
DESCRIPTION Selective 12/15 LOX inhibitor; active in vivo (Tocris Bioactive Compound Library)
DESCRIPTION PIK-93 is a potent PI3K inhibitor. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
4
Compound Sets
20
AdooQ Bioactive Compound Library
A10731
BOC Sciences Bioactive Compounds
pik-93-cas-593960-11-3-item-84-95186
Cayman Chemical Bioactives
10009212
Concise Guide to Pharmacology 2017/18
6062
Concise Guide to Pharmacology 2019/20
6062
Concise Guide to Pharmacology 2021/22
6062
Concise Guide to Pharmacology 2023/24
6062
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB06836
DrugMAP
DM3JBLK
EU-OPENSCREEN Bioactive Compound Library
EOS100640
Guide to Pharmacology
6062
Informer Set
660774
LINCS compound set
10190-101
MedChem Express Bioactive Compound Library
HY-12046
Selleckchem Bioactive Compound Library
PIK-93
TargetMol Bioactive Compound Library
T2616
Tocris Bioactive Compound Library
6440
Welcome Trust Cancer Drugs
303
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
389.03
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
2.0
TPSA
108.39
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
PIK3CG
PI4K,PI3K
ATM
C2??
DNA-PK
hsVps34
mTORC1
p110??
PI3KIII??
PI4KB, PIK3C3, PIK3CG
PI3K
PI4K
Virus Protease
Compound status
probe
Pathway
PI3K signaling
DNA Damage/DNA Repair
Metabolism
Microbiology&virology
PI3K/Akt/mTOR signaling
Anti-infection
PI3K/Akt/mTOR
Primary Target
PI 3-kinase
MOA
Inhibitor
PI3K inhibitor
Solubility
In vitro:<br/>10 mM in DMSO
Source data